Association of sleep characteristics with adiposity markers in children
| Autor: | Antje Körner, Oskar G. Jenni, Johann Daxer, Andreas Merkenschlager, Andreas Hiemisch, Wieland Kiess, Jens Kluge, Mirja Quante, Jürgen Kratzsch, Theresa Herttrich, Kathrin Scheuermann |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male Sleep Wake Disorders Pediatrics medicine.medical_specialty Pediatric Obesity Adolescent Endocrinology Diabetes and Metabolism Polysomnography Ideal Body Weight Overweight Body Mass Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology medicine Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Child Adiposity Sleep Apnea Obstructive medicine.diagnostic_test business.industry Puberty medicine.disease Obesity Confidence interval Obstructive sleep apnea Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Sleep diary Female medicine.symptom business Sleep Body mass index 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Journal of pediatric endocrinologymetabolism : JPEM. 33(7) |
| ISSN: | 2191-0251 |
| Popis: | Background Accumulating evidence suggests a relationship between sleep alterations and overweight/obesity in children. Our aim was to investigate the association of sleep measures other than obstructive sleep apnea or sleep duration with overweight/obesity and metabolic function in children. Methods We conducted a prospective cohort study in school- aged children (aged 5 to 8 years, prepubertal, and 12 to 15 years, pubertal) with overweight/obesity and normal-weight children. All children underwent a standardized in-laboratory polysomnography followed by a fasting blood assessment for glucose and metabolic testing. Subjective sleep measures were investigated by a 7-day sleep diary and questionnaire. We analyzed prepubertal and pubertal groups separately using logistic regression and partial correlation analyses. Results A total of 151 participants were analyzed. Overweight/obese children had significantly higher odds for arousal index (prepubertal children: 1.28, Confidence interval (CI): 1.06, 1.67; pubertal children: 1.65, CI: 1.19, 2.29) than normal-weight children, independent of age and gender. In prepubertal children, arousal-index was positively associated with C-peptide (r=0.30, p=0.01), whereas Minimum O2 saturation was negatively associated with triglycerides (r=−0.34, p=0.005), adjusting for age and sex. However, associations were attenuated by further adjustment for body mass index standard deviation scores (BMI-SDS). In pubertal children, higher level of apnea-hypopnea-index and pCO2 predicted increased lipoprotein (a) levels (r=0.35, p=0.03 and r=0.40, p=0.01, respectively), independent of age, sex, and BMI-SDS. A negative association was found between pCO2 and high-density lipoprotein (HDL)-cholesterol (r=−0.40, p=0.01). Conclusions Overall, we report that sleep quality as measured by arousal index may be compromised by overweight and obesity in children and warrants attention in future intervention programs. |
| Databáze: | OpenAIRE |
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