Lactational competence and involution of the mouse mammary gland require plasminogen
| Autor: | Ib Jarle Christensen, R. Osterby, T.H. Bugge, S.F. Bjorn, M.D. Sternlicht, P.A. Usher, Keld Dano, Z. Werb, H. Solberg, Leif R. Lund, Boye Schnack Nielsen, Ross W. Stephens |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Mammary gland Biology Matrix metalloproteinase Extracellular matrix Mice Mammary Glands Animal Stroma Internal medicine Lactation medicine Animals Involution (medicine) Molecular Biology Urokinase Fibrin Cell Differentiation Plasminogen Urokinase-Type Plasminogen Activator Matrix Metalloproteinases Mice Mutant Strains Extracellular Matrix Fertility medicine.anatomical_structure Endocrinology Matrix Metalloproteinase 9 Female Plasminogen activator Developmental Biology medicine.drug |
| Zdroj: | Publons |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.127.20.4481 |
| Popis: | Urokinase-type plasminogen activator expression is induced in the mouse mammary gland during development and post-lactational involution. We now show that primiparous plasminogen-deficient (Plg−/−) mice have seriously compromised mammary gland development and involution. All mammary glands were underdeveloped and one-quarter of the mice failed to lactate. Although the glands from lactating Plg−/− mice were initially smaller, they failed to involute after weaning, and in most cases they failed to support a second litter. Alveolar regression was markedly reduced and a fibrotic stroma accumulated in Plg−/− mice. Nevertheless, urokinase and matrix metalloproteinases (MMPs) were upregulated normally in involuting glands of Plg−/− mice, and fibrin did not accumulate in the glands. Heterozygous Plg+/− mice exhibited haploinsufficiency, with a definite, but less severe mammary phenotype. These data demonstrate a critical, dose-dependent requirement for Plg in lactational differentiation and mammary gland remodeling during involution. |
| Databáze: | OpenAIRE |
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