Clinical Findings and Prognostic Factors in Chronic Myeloid Leukemias
| Autor: | C. Wedelin, Håkan Mellstedt, Magnus Björkholm, Göran Holm, G. Gahrton |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Poor prognosis Adolescent medicine.medical_treatment Splenectomy Philadelphia chromosome Internal medicine Internal Medicine medicine Humans Philadelphia Chromosome Blast cell count Low hemoglobin Aged Sweden Chronic myeloid leukemias business.industry Myeloid leukemia Middle Aged Prognosis medicine.disease Blood Cell Count Leukemia Leukemia Myeloid Immunology Female Blast Crisis business |
| Zdroj: | Acta Medica Scandinavica. 220:255-260 |
| ISSN: | 0001-6101 |
| Popis: | Ninety-one previously untreated patients with chronic myeloid leukemia admitted to three Stockholm hospitals 1973-1978 were studied. There were 49 men and 42 women with a mean age of 56 years (range 15-93). Sixty-five patients were Philadelphia chromosome (Ph1) positive and 17 were Ph1 negative (mean age 51 and 70 years, respectively). After a mean observation time of 5.2 years, 64 patients had deceased, 45 of them in blast transformation. A low hemoglobin value and a high total blast cell count at diagnosis were associated with a poor prognosis in the Ph1 positive group. Other routine clinical and laboratory variables were of subordinate prognostic importance. Early splenectomy in 15 Ph1 positive patients did not improve survival. Median survival from diagnosis was 38 months for Ph1 positive patients as compared to 12 months for the Ph1 negative group. |
| Databáze: | OpenAIRE |
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