Human immunodeficiency virus type 1 (HIV-1)--and Epstein-Barr virus--specific cytotoxic T lymphocyte precursors exhibit different kinetics in HIV-1--infected persons
| Autor: | Folko J. Wijnholds, Jan C. C. Borleffs, Albert D. M. E. Osterhaus, Marlinda E. M. Dings, Anna M. Geretti, Cécile A. C. M. van Els, Carel A. van Baalen |
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| Rok vydání: | 1996 |
| Předmět: |
Cytotoxicity
Immunologic Herpesvirus 4 Human CD8 Antigens Gene Products gag Genes MHC Class I Biology medicine.disease_cause Lymphocyte Activation Peripheral blood mononuclear cell Virus Antigen medicine Immunology and Allergy Cytotoxic T cell Humans Longitudinal Studies B cell Acquired Immunodeficiency Syndrome T lymphocyte Cytotoxicity Tests Immunologic Epstein–Barr virus Virology Kinetics Infectious Diseases medicine.anatomical_structure Immunology CD4 Antigens Disease Progression HIV-1 CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | The Journal of infectious diseases. 174(1) |
| ISSN: | 0022-1899 |
| Popis: | The frequencies of human immunodeficiency virus type 1 (HIV-1) Gag- and Epstein-Barr virus (EBV)-specific cytotoxic T lymphocyte precursors (CTLp) were studied longitudinally in peripheral blood mononuclear cells from 9 HIV-1-infected persons. By antigen-specific stimulation, HIV-1 Gag-specific CTLp were detected in vitro throughout the course of HIV-1 infection, even after the onset of overt disease. In 4 patients, however, HIV-1 Gag-specific CTLp frequencies declined over time in the presence of maintained EBV-specific CTLp. This decline was correlated with decreasing CD4 (r = .38; P < .05) and CD8 (r = .75; P < .001) cell numbers. The maintenance of EBV-specific CTLp in patients with low CD4 cell numbers indicated that EBV-specific CTL-mediated immunity may remain longer unaffected by HIV-1-induced immune dysfunction. Consistent with this observation, the growth of EBV-specific CTL could be supported in vitro by EBV-infected lymphoblastoid B cell lines, independent of both CD4 cells and exogenous cytokines. |
| Databáze: | OpenAIRE |
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