The Changes of Serum Triiodothyronine, Thyroxine and Thyroid Stimulating Hormone in Two Cases of Hypothyroidism with Unusual Complications
| Autor: | Shintaro Saito, Toru Yamaguchi, Makiko Yamamoto, Toshiro Sakurada, Rikiya Abe, Katsumi Yoshida, Kaoru Yoshinaga |
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| Rok vydání: | 1974 |
| Předmět: |
Male
endocrine system medicine.medical_specialty endocrine system diseases Exophthalmos Feedback control Radioimmunoassay Thyroid Gland Thyrotropin Deafness General Biochemistry Genetics and Molecular Biology Hypothyroidism Thyroid-stimulating hormone TSH secretion Internal medicine Myxedema medicine Humans Child Triiodothyronine Goiter business.industry Pretibial myxedema Thyroid Syndrome General Medicine Middle Aged medicine.disease Thyroxine Endocrinology medicine.anatomical_structure medicine.symptom business hormones hormone substitutes and hormone antagonists Triiodothyronine/Thyroxine |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 112:365-371 |
| ISSN: | 1349-3329 0040-8727 |
| Popis: | In a case of hypothyroidism with clubbing of fingers and toes, exophthalmos, myxoedema tuberosum and myxoedema pretibiale, serum T4 value was low, but both values of serum T3 and TSH were normal and serum LATS was potitive. Three months later both values of serum T4 and T3 decreased and serum TSH value increased without any treatment. These results show that serum T3 as well as T4 might be related to the feedback control of TSH secretion. In a case of Pendred's syndrome, serum T4 value was low, values of serum T3 and BMR were within normal and serum TSH value was high. Normal serum T3 may have kept this patient in a state of compensatory hypothyroidism. In these patients, administration of 25-50 μg of l-T3 per day was sufficient to suppress the secretion of serum TSH from thyroid gland completely. |
| Databáze: | OpenAIRE |
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