Stage I and II Stress Incontinence (SIC): High dosed vitamin D may improve effects of local estriol
| Autor: | Doru Craiut, Claus Schulte-Uebbing, Gheorghe Adrian Bumbu, Siegfried Schlett |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
cholecalciferol
Vitamin Stress incontinence medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Urology vitamin D 030209 endocrinology & metabolism Dermatology estriol vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Vitamin D and neurology Morning SIC Gynecology pelvic floor weakness business.industry Estriol high dosed vaginal vitamin D medicine.disease stress incontinence chemistry Estrogen 030220 oncology & carcinogenesis business Cholecalciferol Research Paper |
| Zdroj: | Dermato-endocrinology |
| ISSN: | 1938-1980 |
| DOI: | 10.1080/19381980.2015.1079359 |
| Popis: | After the age of 55 almost every third woman suffers from conditions of the incapability to retain urine when the intra-abdominal pressure is raised by different causes. So called stress incontinence. It’ s caused by a predisposition in the family, weakness of the tissue, physical strain, deficiency in the metabolism, especially an increasing local estrogen deficiency and a local and systemic vitamin D deficiency. Patients: We evaluated the data of 60 meno- and postmenopausal female patients with a stress incontinence (SIC). All had a SIC in spite of a former local estriol treatment with a treatment of OeKolp® forte (= 0.5 mg estriol/ov), 3 times a week, for 6 weeks and in spite of a regular pelvic floor exercise for 6 weeks in the morning and in the evening, according to the protocol. Thirty were in stage I SIC and 30 were in stage II SIC. Method: We evaluated vitamin-D-levels in serum of our 60 postmenopausal women. Only 20% of this group had good vitamin D-levels. The medical intervention combined estriol (0.5 mg) together with high dosed vitamin D (12.500 I.U.) locally 3 times a week for a period of 6 weeks. The patients also had the instruction to continue their daily exercises in pelvic floor (morning and evening, due to their protocol). After six weeks of treatment the vitamin D level in serum was defined and correlated to the patients condition (symptomatic of stress incontinence, protocol of micturitions, Pad-test). Results: About one-third of women from our test assigned to be now capable of retaining urine. More than one-third of our patients cleared a profit of treatment. They reported mimimum regression about 25% of volume of incontinence. Therefore more than 2-third of our women being incapable of retaining urine improved their body conditions by using a combination of locally administered etriol and high dosed vitamin D. Conclusion: Stress incontinence (being incapable of retaining urine when the intra-abdominal pressure arises) in lower and middle grade, improves their body conditions under a combination of local administered estriol and vitamin D. This small study is not representative. We need much bigger studies with much more dates and with a follow up. |
| Databáze: | OpenAIRE |
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