Acid-Switchable DNAzyme Nanodevice for Imaging Multiple Metal Ions in Living Cells
| Autor: | Xiang-Ling Li, Mei-Rong Cui, Jing-Juan Xu, Hong-Yuan Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Metal ions in aqueous solution Cytological Techniques Deoxyribozyme Nucleic Acid Hybridization Nanotechnology 02 engineering and technology DNA Catalytic 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Catalysis Highly sensitive Nanostructures HEK293 Cells Metals Heavy MCF-7 Cells Humans General Materials Science 0210 nano-technology Nanodevice Acids HeLa Cells |
| Zdroj: | ACS applied materialsinterfaces. 12(11) |
| ISSN: | 1944-8252 |
| Popis: | Metal-assisted deoxyribozyme catalysis (DNAzyme) has been a general platform for constructing highly sensitive and selective detection sensors of metal ions. However, the "always on" mode of the traditional DNAzyme sensors greatly limits their application in the visual analysis of endogenous metal ions in a complex physiological microenvironment. To overcome this obstacle, a smart acid-switchable DNAzyme nanodevice is designed to control the DNAzyme activity in living cells and achieve simultaneous visualization of metal ions (Zn |
| Databáze: | OpenAIRE |
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