Isolation and structure elucidation of a novel antimalarial macrocyclic polylactone, menisporopsin A, from the fungus Menisporopsis theobromae
| Autor: | Pacharee Maithip, Masahiko Isaka, Maneekarn Chinworrungsee, Yodhathai Thebtaranonth, Sumalee Supothina, Prasat Kittakoop |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.drug_class
Stereochemistry Plasmodium falciparum Pharmaceutical Science Biology Antimycobacterial Analytical Chemistry chemistry.chemical_compound Antimalarials Inhibitory Concentration 50 Drug Discovery medicine Animals Phenols Nuclear Magnetic Resonance Biomolecular Antibacterial agent Benzoic acid Pharmacology chemistry.chemical_classification Molecular Structure Organic Chemistry Absolute configuration Fungi Biological activity Thailand Chiral column chromatography Complementary and alternative medicine chemistry Molecular Medicine Macrolides Lactone |
| Zdroj: | Journal of natural products. 67(4) |
| ISSN: | 0163-3864 |
| Popis: | An antimalarial macrocyclic polylactone, menisporopsin A (1), was isolated from a cell extract of the seed fungus Menisporopsis theobromae. The structure of 1 was elucidated on the basis of spectroscopic analysis and chemical transformations, with the absolute configuration established by application of the modified Mosher method and by using chiral HPLC. Menisporopsin A (1) possesses an unprecedented residue, 2,4-dihydroxy-6-(2,4-dihydroxy-n-pentyl)benzoic acid. This compound exhibited antimalarial activity, with an IC(50) value of 4.0 microg mL(-1), and antimycobacterial activity (MIC value of 50 microg mL(-1)). |
| Databáze: | OpenAIRE |
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