Gender- and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Based Water-Fat MRI

Autor: Kerensa M. Beekman, Martine Regenboog, Aart J. Nederveen, Nathalie Bravenboer, Martin den Heijer, Peter H. Bisschop, Carla E. Hollak, Erik M. Akkerman, Mario Maas
Přispěvatelé: Graduate School, Radiology and Nuclear Medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Movement Sciences, ACS - Diabetes & metabolism, AMS - Ageing & Vitality, AMS - Sports, Endocrinology, AMS - Musculoskeletal Health, Amsterdam Neuroscience - Brain Imaging, AMS - Rehabilitation & Development, Radiology and nuclear medicine, Internal medicine, Elderly care medicine, Clinical chemistry, AMS - Tissue Function & Regeneration, VU University medical center, APH - Health Behaviors & Chronic Diseases, APH - Aging & Later Life, ACS - Heart failure & arrhythmias
Rok vydání: 2021
Předmět:
Zdroj: Frontiers in Endocrinology, 13. FRONTIERS MEDIA SA
Frontiers in endocrinology, 13:815835. Frontiers Media S.A.
Beekman, K M, Regenboog, M, Nederveen, A J, Bravenboer, N, den Heijer, M, Bisschop, P H, Hollak, C E, Akkerman, E M & Maas, M 2022, ' Gender-and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Based Water-Fat MRI ', Frontiers in Endocrinology, vol. 13, 815835, pp. 815835 . https://doi.org/10.3389/fendo.2022.815835
Frontiers in Endocrinology, 13:815835. Frontiers Media S.A.
ISSN: 1664-2392
DOI: 10.3389/fendo.2022.815835
Popis: Bone marrow adipose tissue (BMAT) is a dynamic tissue which is associated with osteoporosis, bone metastasis, and primary bone tumors. The aim of this study is to determine region-specific variations and age- and gender-specific differences in BMAT and BMAT composition in healthy subjects. In this cross-sectional study, we included 40 healthy subjects (26 male: mean age 49 years, range 22–75 years; 14 female: mean age 50 years, range 29–71) and determined the bone marrow signal fat fraction and bone marrow unsaturation in the spine (C3-L5), pelvis, femora, and tibiae using chemical shift encoding-based water–fat imaging (WFI) with multiple gradient echoes (mGRE). Regions of interest covered the individual vertebral bodies, pelvis and proximal epimetaphysis, diaphysis, and distal epimetaphysis of the femur and tibia. The spinal fat fraction increased from cervical to lumbar vertebral bodies (mean fat fraction ( ± SD or (IQR): cervical spine 0.37 ± 0.1; thoracic spine 0.41 ± 0.08. lumbar spine 0.46 ± 0.01; p < 0.001). The femoral fat fraction increased from proximal to distal (proximal 0.78 ± 0.09; diaphysis 0.86 (0.15); distal 0.93 ± 0.02; p < 0.001), while within the tibia the fat fraction decreased from proximal to distal (proximal 0.92 ± 0.01; diaphysis 0.91 (0.02); distal 0.90 ± 0.01; p < 0.001). In female subjects, age was associated with fat fraction in the spine, pelvis, and proximal femur (ρ = 0.88 p < 0.001; ρ = 0.87 p < 0.001; ρ = 0.63 p = 0.02; ρ = 0.74 p = 0.002, respectively), while in male subjects age was only associated with spinal fat fraction (ρ = 0.40 p = 0.04). Fat fraction and unsaturation were negatively associated within the spine (r = -0.40 p = 0.01), while in the extremities fat fraction and unsaturation were positively associated (distal femur: r = 0.42 p = 0.01; proximal tibia: r = 0.47, p = 0.002; distal tibia: r = 0.35 p = 0.03), both independent of age and gender. In conclusion, we confirm the distinct, age- and gender-dependent, distribution of BMAT throughout the human skeleton and we show that, contradicting previous animal studies, bone marrow unsaturation in human subjects is highest within the axial skeleton compared to the appendicular skeleton. Furthermore, we show that BMAT unsaturation was negatively correlated with BMAT within the spine, while in the appendicular skeleton, BMAT and BMAT unsaturation were positively associated.
Databáze: OpenAIRE
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