Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats
Autor: | Cristophod de Souza dos Santos, Betânia Souza de Freitas, Maria Noêmia Martins de Lima, Vinicius Antoniazzi, Juliano Viana Borges, Leticia Paludo, Vivian Naziaseno Pires, Kelem Vedovelli, Elke Bromberg |
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Rok vydání: | 2019 |
Předmět: |
Male
medicine.medical_specialty Anxiety Hippocampal formation Histone Deacetylases Open field Epigenesis Genetic Histones 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Neurotrophic factors Internal medicine medicine Animals Cognitive Dysfunction Chronic stress Rats Wistar Cognitive decline Social isolation 030304 developmental biology Brain-derived neurotrophic factor Social stress Memory Disorders 0303 health sciences business.industry Brain-Derived Neurotrophic Factor Social Support Acetylation Rats Endocrinology Social Isolation medicine.symptom business Stress Psychological 030217 neurology & neurosurgery |
Zdroj: | Behavioural Brain Research. 366:36-44 |
ISSN: | 0166-4328 |
DOI: | 10.1016/j.bbr.2019.03.025 |
Popis: | Epigenetic modulation of brain-derived neurotrophic factor (BDNF) provides one possible explanation for the dysfunctions induced by stress, such as psychiatric disorders and cognitive decline. Interestingly, social support can be protective against some of these effects, but the mechanisms of social buffering are poorly understood. Conversely, early isolation exacerbates the responses to stressors, although its effects in adulthood remain unclear. This study investigated the effects of social isolation and social buffering on hippocampal epigenetic mechanisms, BDNF levels and behavioral responses of chronically stressed young adult rats. Male Wistar rats (3 months) were assigned to accompanied (paired) or isolated housing. After one-month half of each group was submitted to a chronic unpredictable stress (CUS) protocol for 18 days. Among accompanied animals, only one was exposed to stress. Behavioral analysis encompassed the Open field, plus maze and inhibitory avoidance tasks. Hippocampal H3K9 and H4K12 acetylation, HDAC5 expression and BDNF levels were evaluated. Isolated housing increased HDAC5 expression, decreased H3K9 and H4K12 acetylation, reduced BDNF levels, and impaired long-term memory. Stress affected weight gain, induced anxiety-like behavior and decreased AcK9H3 levels. Interactions between housing conditions and social stress were seen only for HDAC5 expression, which showed a further increase in the isolated + CUS group but remained constant in accompanied animals. In conclusion, social isolation at adulthood induced epigenetic alterations and exacerbated the effects of chronic stress on HDAC5. Notwithstanding, social support counteracted the adverse effects of stress on HDAC5 expression. |
Databáze: | OpenAIRE |
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