Effects of centipedic acid on acute lung injury: A dose-response study in a murine model

Autor:	Fladimir, de Lima Gondim, Marcelle Ferreira, Moura, Allison Matias, de Sousa, Ruth Mesquita, Ferreira, Daniel Silveira, Serra, Mary Anne Sousa, Lima, Antônia Torres Ávila, Pimenta, Walter Araujo, Zin, Francisco Sales Ávila, Cavalcante
Rok vydání:	2023
Předmět:	Pulmonary and Respiratory Medicine Physiology General Neuroscience
Zdroj:	Respiratory Physiology & Neurobiology. 310:103988
ISSN:	1569-9048
Popis:	Centipedic Acid (CPA), a natural diterpene from Egletes viscosa, an endemic species of the Caatinga biome, has shown antioxidant and anti-inflammatory properties. However, no report on the CPA on respiratory system mechanics has been so far advanced. We aimed to investigate the dose-response behavior of CPA on E. coli lipopolysaccharide (LPS)-triggered acute lung injury (ALI). Forty-eight C57BL/6 mice were randomly divided into six groups: control (SS), induced to ALI (LPS), 4 groups induced to ALI pre-treated with 12.5, 25, 50 and 100mg/kg of CPA (CPA12.5, CPA25, CPA50 and CPA100 groups). CPA 100mg/kg could prevent inflammatory cell infiltration, alveolar collapse, changes in tissue micromechanics and lung function (airway resistance, tissue elastance, tissue resistance and Static compliance). These results indicate preventive potential of this compound in the installation of ALI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af7f925f29e8917549474dfa50b7dd1 https://doi.org/10.1016/j.resp.2022.103988 Zobrazit plný text záznamu Full Text from ScienceDirect