Maturation and segregation of brain networks that modify seizures
| Autor: | Lucy L. Brown, R.S. Zukin, Solomon L. Moshé, Hana Kubová, Ellen F. Sperber, Jana Velíšková |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Protein subunit Central nervous system Substantia nigra Biology Rats Sprague-Dawley Epilepsy Seizures Gene expression medicine Animals RNA Messenger Receptor Molecular Biology In Situ Hybridization Brain Mapping Histocytochemistry GABAA receptor General Neuroscience Receptors GABA-A medicine.disease Rats medicine.anatomical_structure nervous system Convulsant Neurology (clinical) Nerve Net Neuroscience Developmental Biology |
| Zdroj: | Brain Research. 665:141-146 |
| ISSN: | 0006-8993 |
| Popis: | The mature brain is less susceptible to seizures than the immature brain. We demonstrate that in the mature substantia nigra (SN) there are two topographically discrete GABA A -sensitive regions which differ in the amount of mRNA expression of the GABAA a receptor δ1 subunit. These two regions mediate separate anticon convulsant and preconvulsant and preconvulsant effects and use of diverge projection networks. By contrast, in the immature SN there is no special topography of mRNA expression of the α1 subunit and only the preconvulsant network is present. The decreased seizure susceptibility of the mature brain may be related to postnatal segregation of GABA a -sensitive networks. |
| Databáze: | OpenAIRE |
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