Correlations Between Resting Regional Wall Motion and Regional Myocardial Blood Flow (at Rest and During Exercise) in lnfarct-Related Myocardium
| Autor: | Takashi Katagiri, Yasushi Akutsu, Tetsurou Michihata, Hideyuki Yamanaka, Mitsugu Hasegawa, Mitsuo Kashida, Kenichi Harumi, Takuya Watanabe, Osamu Okazaki |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Physiology Heart Ventricles Rest Myocardial Infarction Anterior wall Ammonia Coronary Circulation medicine Animals Humans Wall motion Myocardial infarction Rest (music) Aged Nitrogen Radioisotopes medicine.diagnostic_test (13N)Ammonia business.industry Gated Blood-Pool Imaging Blood flow Middle Aged medicine.disease Positron emission tomography Exercise Test Arterial blood Female Cardiology and Cardiovascular Medicine Nuclear medicine business Tomography Emission-Computed |
| Zdroj: | Japanese Circulation Journal. 61:665-672 |
| ISSN: | 1347-4839 0047-1828 |
| Popis: | We evaluated quantitatively the correlations between resting wall motion and regional myocardial blood flow (RMBF; at rest and during exercise) in infarct-related myocardium. The study was performed in 28 subjects: 21 patients who had previously suffered myocardial infarction of the anteroseptal wall, and 7 normal individuals. Positron emission tomography (PET) with [13N]ammonia was performed at rest and during low-grade exercise (bicycle ergometer fixed at 25 W for 6.5 min), and RMBF was measured quantitatively from the radioactivity in myocardial tissue and arterial blood. Resting regional wall motion was calculated using the centerline method on left ventriculographic findings. Resting regional wall motion was correlated with RMBF both at rest and during exercise in the infarct areas (anterior walls; y = 2.74 +/- 4.25 x 10(-2)x, r = 0.43, at rest; and y = -2.48 + 3.04 x 10(-2)x, r = 0.48, during exercise, p0.05; septal walls; y = -3.61 + 5.64 x 10(-2)x, r = 0.62, at rest; and y = -3.46 + 4.31 x 10(-2)x, r = 0.62, during exercise, p0.01). In each infarct-related wall, the coefficient (the slope) during exercise was smaller than that at rest (3.04 vs 4.25 and 4.31 vs 5.64 in each), and the infarct areas with preserved wall motion showed higher RMBF during exercise than those with reduced wall motion. Our results may show that wall motion depends on viable but ischemic myocardium in infarct-related walls. |
| Databáze: | OpenAIRE |
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