Overt primary hypothyroidism in an industrial area in São Paulo, Brazil: the impact of public disclosure

Autor: Carmen Diva Saldiva de André, Maria Angela Zaccarelli-Marino, Julio M. Singer
Rok vydání: 2016
Předmět:
Male
Pediatrics
Health
Toxicology and Mutagenesis
ESTATÍSTICA APLICADA
lcsh:Medicine
Thyroid Function Tests
0302 clinical medicine
Risk Factors
Medicine
030212 general & internal medicine
Child
Aged
80 and over
Triiodothyronine
Thyroid
Primary hypothyroidism
autoimmune thyroiditis
Middle Aged
industrial environment
petroleum byproducts
primary hypothyroidism
medicine.anatomical_structure
Child
Preschool
Female
Thyroid function
Brazil
Adult
medicine.medical_specialty
Adolescent
030209 endocrinology & metabolism
Disclosure
Article
Odds
Autoimmune thyroiditis
Young Adult
03 medical and health sciences
Hypothyroidism
Internal medicine
Humans
Industry
Risk factor
Aged
business.industry
lcsh:R
Infant
Newborn
Public Health
Environmental and Occupational Health
Infant
Odds ratio
medicine.disease
Endocrinology
business
Zdroj: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
International Journal of Environmental Research and Public Health, Vol 13, Iss 11, p 1161 (2016)
International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health; Volume 13; Issue 11; Pages: 1161
Popis: Background: Primary hypothyroidism (PH) is the most common thyroid pathology. Purpose: to evaluate the impact of public disclosure of an unexpected number of PH cases on the frequency of patients seeking medical evaluation for endocrinological diseases. Methods: data on 6306 subjects (3356 living in the surroundings of a petrochemical complex and 2950 in a control region) were collected over a 15-year time span. Thyroid function was determined by serum levels of triiodothyronine, thyroxine, free thyroxine and thyrotrophin. Antithyroglobulin and antithyroperoxidase antibodies and sonographic scans of the thyroid were performed in all patients. The data were analyzed via log-linear models to compute odds and odds ratios. Results: An increasing trend in the odds of PH was detected along the observation period with greater slope in the study region than in the control region. The odds of PH in the post-disclosure period (2002 to 2004) are greater than the corresponding ones in the pre-disclosure period (1989 to 2001). Conclusions: This study shows that living in the surroundings of a petrochemical complex may be an important risk factor for PH for both adults and children. Furthermore, public disclosure of such risk factor contributes to the awareness of the problem and to the possibility of an early diagnosis.
Databáze: OpenAIRE
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