Tailored poly(ethylene) glycol dimethacrylate based shape memory polymer for orthopedic applications
Autor: | S. Raja, S.T. Aruna, G. Jerald Maria Antony, Chethan S. Jarali |
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Rok vydání: | 2016 |
Předmět: |
Materials science
Biocompatibility Polymers Radical polymerization Biomedical Engineering Nanotechnology Biocompatible Materials 02 engineering and technology 010402 general chemistry Methacrylate 01 natural sciences Cell Line Polyethylene Glycols Biomaterials chemistry.chemical_compound Humans Transition Temperature chemistry.chemical_classification Acrylate Temperature Polymer Ethylenes 021001 nanoscience & nanotechnology 0104 chemical sciences Shape-memory polymer Orthopedics chemistry Chemical engineering Mechanics of Materials Methacrylates 0210 nano-technology Glass transition Ethylene glycol |
Zdroj: | Journal of the mechanical behavior of biomedical materials. 65 |
ISSN: | 1878-0180 |
Popis: | Shape-memory polymers (SMPs) are stimuli-responsive materials known for their outstanding ability to be actuated from temporary shape into original shape. Because of this unique functionality SMPs are promising materials for diverse technological applications including smart biomedical devices. In this article, the work has been focused towards tailoring the SMP precursor and crosslinker wt% to obtain biocompatible acrylate based shape memory polymer with glass transition temperature (Tg) close to human body temperature. Methacrylate based shape memory polymer networks are synthesized via free radical polymerization by varying the wt% of t-butyl acrylate (tBA) and poly(ethylene glycol) dimethacrylate (PEGDMA) as crosslinker. The Tg is found to increase from 28 to 45 °C with increasing tBA amount. The SMP synthesized from 70 wt% of tBA and 30 wt% of PEGDMA possess Tg close to human body temperature and is tested for cytotoxicity with two different cell lineages, osteosarcoma (MG-63) cells, and human keratinocyte (HaCaT) cells. The synthesized SMP is found to be non-cytotoxic. Thus the investigated biocompatible shape memory polymer network can be a promising soft substrate for passive thermomechanical stimulation which can adapt and meet specific needs of in vitro or in vivo orthopedic Superior Labrum Anterior and Posterior (SLAP) medical devices. |
Databáze: | OpenAIRE |
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