Interferon-γ release assays for the diagnosis of Mycobacterium tuberculosis infection in children: a systematic review and meta-analysis
| Autor: | Francesca Bonsignori, Luisa Galli, M. De Martino, Gabriele Accetta, Annibale Biggeri, V. Boddi, Elena Chiappini |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Tuberculosis Immunology Tuberculin Bioinformatics Sensitivity and Specificity Mycobacterium tuberculosis Interferon-gamma Interferon γ Tuberculosis diagnosis Predictive Value of Tests Internal medicine medicine Immunology and Allergy Humans Lymphocytes Child Pharmacology biology business.industry Tuberculin Test Age Factors Skin test bacterial infections and mycoses medicine.disease biology.organism_classification Predictive value of tests Meta-analysis business Biomarkers Interferon-gamma Release Tests |
| Zdroj: | Europe PubMed Central Università degli studi di Firenze-IRIS Scopus-Elsevier |
| ISSN: | 0394-6320 |
| Popis: | Data regarding the use of Interferon-gamma release assays (IGRAs) for tuberculosis diagnosis are accumulating. We systematically searched PubMed, EMBASE and Cochrane and performed pooled estimates of sensitivity and specificity of QuantiFERON-TB Gold In Tube (QFT-G-IT) and T-SPOT. TB compared to tuberculin skin test (TST). For studies assessing sensitivity, children had to have active tuberculosis. Specificity data were derived from children classified as non-infected. Eleven studies were included in the sensitivity analysis for TST, 10 for QFT-G-IT, and 9 for T-SPOT.TB. Eight studies were included in specificity analysis for TST, 8 for QFT-G-IT, and 7 for T-SPOT.TB. Pooled QFT-G-IT sensitivity was 0.79 (95%CI:0.70–0.89) pooled T-SPOT.TB sensitivity was 0.74 (95%CI:0.59–0.90) and pooled TST sensitivity was 0.82 (95%CI:0.72–0.93). Pooled QFT-G-IT and T-SPOT.TB specificities were 0.95 (95%CI:0.93–0.97) and 0.96 (95%CI:0.93–1.00), respectively. Pooled TST specificity was significantly lower 0.83 (95%CI:0.74–0.92). IGRA performance in children showed no better sensitivity than TST, but higher specificity. |
| Databáze: | OpenAIRE |
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