Successful mepolizumab treatment for DRESS-induced refractory eosinophilic myocarditis and concurrent thyroiditis
| Autor: | Kelvin Truong, Annika Smith, Shane Kelly, Angela Bayly |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
medicine.medical_specialty
Thyroiditis Myocarditis Interstitial nephritis Antibodies Monoclonal Humanized 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Prospective Studies Pneumonitis business.industry General Medicine medicine.disease Dermatology 030220 oncology & carcinogenesis Drug Hypersensitivity Syndrome Pancreatitis business Meningitis Mepolizumab Adverse drug reaction medicine.drug |
| Zdroj: | BMJ case reports. 14(7) |
| ISSN: | 1757-790X |
| Popis: | Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening adverse drug reaction with a mortality rate of 10%. Interstitial nephritis, pneumonitis, myocarditis, meningitis, thyroiditis and pancreatitis are major causes of morbidity and mortality in this syndrome. Cessation of offending medication is paramount. There is paucity in high quality prospective studies guiding the treatment of DRESS, and there are no published therapeutic clinical trials in the treatment of corticosteroid refractory hypersensitivity myocarditis. The authors present a unique case of ciprofloxacin-induced DRESS with concurrent thyroiditis and refractory eosinophilic myocarditis that required mepolizumab and multiple immunosuppressants for successful treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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