Absence of major fibrotic adverse events in hyperprolactinemic patients treated with cabergoline
| Autor: | P. M. J. Zelissen, F Teding van Berkhout, Melvin Lafeber, M J Cramer, G D Valk, A M E Stades |
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| Přispěvatelé: | Internal Medicine, Erasmus School of Economics |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Lung Diseases
Male medicine.medical_specialty Cabergoline Endocrinology Diabetes and Metabolism Heart Valve Diseases Blood Sedimentation Retroperitoneal fibrosis Statistics Nonparametric Pulmonary function testing Electrocardiography Endocrinology Fibrosis Internal medicine Acromegaly medicine Humans Ergolines Adverse effect Lung Cumulative dose business.industry Retroperitoneal Fibrosis General Medicine Middle Aged medicine.disease Heart Valves Respiratory Function Tests Hyperprolactinemia C-Reactive Protein Cross-Sectional Studies Echocardiography Creatinine Dopamine Agonists Female medicine.symptom Complication business Glomerular Filtration Rate medicine.drug |
| Zdroj: | European Journal of Endocrinology, 162(4), 667-75. Bioscientifica Ltd |
| ISSN: | 0804-4643 |
| DOI: | 10.1530/eje-09-0989 |
| Popis: | BackgroundCabergoline, a dopamine agonist used to treat hyperprolactinemia, is associated with an increased risk of fibrotic adverse reactions, e.g. cardiac valvular fibrosis, pleuropulmonary, and retroperitoneal fibrosis.ObjectiveThis study evaluated the prevalence and risk of fibrotic adverse reactions during cabergoline therapy in hyperprolactinemic and acromegalic patients.DesignA cross-sectional study was conducted in a University Hospital.PatientsA total of 119 patients with hyperprolactinemia and acromegaly who were on cabergoline therapy participated in the study.MethodsAll patients were requested to undergo a cardiac assessment, pulmonary function test, chest X-ray, and blood tests as recommended by the European Medicine Agency. Matched controls were recruited to compare the prevalence of valvular regurgitation. Cardiac valvular fibrosis was evaluated by assessing valvular regurgitation and the mitral valve tenting area (MVTa). The risk of pleuropulmonary fibrosis was assessed by a pulmonary function test, a chest X-ray, and if indicated, by additional imaging studies.ResultsThe prevalence of clinically relevant valvular regurgitation was not significantly different between cases (11.3%) and controls (6.1%; P=0.16). The mean MVTa was 1.27±0.17 and 1.24±0.21 cm2 respectively (P=0.54). Both valvular regurgitation and the MVTa were not related to the cumulative dose of cabergoline. A significantly decreased pulmonary function required additional imaging in seven patients. In one patient, possible early interstitial fibrotic changes were seen. Lung function impairment was not related to the cumulative cabergoline dose.ConclusionCabergoline, typically dosed for the long-term treatment of hyperprolactinemia or acromegaly, appears not to be associated with an increased risk of fibrotic adverse events. |
| Databáze: | OpenAIRE |
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