Cytomegalovirus, human herpesvirus-6, and human herpesvirus-7 in adult liver transplant recipients: diagnosis based on antigenemia
| Autor: | A.M. Sampaio, Raquel Silveira Bello Stucchi, Sandra Cecília Botelho Costa, Cláudio Lúcio Rossi, Ilka de Fátima Santana Ferreira Boin, Ronaldo Luis Thomasini, A.C. Guardia |
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| Rok vydání: | 2011 |
| Předmět: |
Human cytomegalovirus
Male medicine.medical_specialty Time Factors viruses medicine.medical_treatment Herpesvirus 6 Human Congenital cytomegalovirus infection Cytomegalovirus Roseolovirus Infections Herpesvirus 7 Human Liver transplantation medicine.disease_cause Herpesviridae Organ transplantation Immunoenzyme Techniques Predictive Value of Tests medicine Humans Prospective Studies Antigens Viral Transplantation biology business.industry virus diseases Immunosuppression biochemical phenomena metabolism and nutrition Middle Aged biology.organism_classification medicine.disease Liver Transplantation surgical procedures operative Immunology Cytomegalovirus Infections Surgery Human herpesvirus 6 Female Virus Activation business Biomarkers Brazil Immunosuppressive Agents |
| Zdroj: | Transplantation proceedings. 43(4) |
| ISSN: | 1873-2623 |
| Popis: | Human herpesvirus (HHV)-6, HHV-7, and cytomegalovirus (CMV) that remain latent after primary infection can be reactivated during immunosuppression following organ transplantation in liver transplant recipients. The aim of this study was to monitor active infections for HHV-6, HHV-7, and CMV among adult liver transplantation recipients using antigenemia detected by an immunoperoxidase staining. Twenty-eight adult liver transplant patients were monitored using antigenemia in blood samples obtained at the time of transplantation, as well as weekly in the first month and once a month for 6 months. Of these patients, 28.5% showed positive CMV antigenemia; 39.2%, HHV-6 antigenemia; and 14.2%, HHV-7 antigenemia. The detection of the three viruses was considered to be independent of one another (P > .05). The results described above showed that few patients remain free of beta herpesviruses after liver transplantation. Most patients were infected sequentially and not concurrently. Antigenemia has been considered useful to detect active HHV-6 and HHV-7 infections. Antigenemia can be more efficiently interpreted when compared with polymerase chain reaction results, although other studies are necessary to establish the reference of HHV-6 and HHV-7 antigenemia. |
| Databáze: | OpenAIRE |
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