Chronic hepatitis C genotype 6 responds better to pegylated interferon and ribavirin combination therapy than genotype 1
| Autor: | K H Chan, Yee-Man Kan, Fu-Hang Lo, Thomas Sik-To Lai, Reggie S.T Li, Jacky Man Chun Chan, Jonpaul S.T Zee, Wai-Keung Kwan, Owen Tak-Yin Tsang, Kent W.L Cheung, David Alan Chow, Francis T.W Li, Michael K. K. Li, Fook-Hong Ng, Yat-Wah Yeung |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Time Factors Biopsy medicine.disease_cause Gastroenterology Polyethylene Glycols chemistry.chemical_compound Risk Factors Pegylated interferon Interferon Genotype Medicine medicine.diagnostic_test Age Factors Hepatitis C Middle Aged Viral Load Recombinant Proteins Phenotype Treatment Outcome Liver biopsy Hong Kong RNA Viral Drug Therapy Combination Female medicine.drug Adult Hepatitis B virus medicine.medical_specialty Adolescent Combination therapy Hepatitis C virus Interferon alpha-2 Antiviral Agents Risk Assessment Young Adult Internal medicine Ribavirin Humans Aged Retrospective Studies Chi-Square Distribution Hepatology business.industry Interferon-alpha Hepatitis C Chronic medicine.disease Logistic Models chemistry Immunology business |
| Zdroj: | Journal of Gastroenterology and Hepatology. 25:766-771 |
| ISSN: | 1440-1746 0815-9319 |
| DOI: | 10.1111/j.1440-1746.2009.06163.x |
| Popis: | Background and Aims: Chronic hepatitis C genotype 6 is common in Hong Kong, especially among i.v. drug abusers. Responses of these patients to combination of pegylated interferon and ribavirin treatment were inconsistent and the numbers of patients involved in previous studies were small. We performed a retrospective study to compare the therapeutic responses of this regimen in patients infected with genotype 6 and genotype 1. Methods: Seventy patients with either genotype 6 or genotype 1 were recruited. Both groups received 800–1200 mg of ribavirin daily plus either 180 mg of pegylated α-interferon-2a or 1.5 mg/kg pegylated α-interferon-2b weekly for 48 weeks. Their responses to treatments were compared. Results: The early virological response to combination therapy of patients with genotype 6 was significantly better than that of genotype 1 (88.6% vs 74.3%, P = 0.03). Significant difference was also identified in the end of treatment response of the two genotypes (60% vs 81.4% for genotype 1 and 6, respectively; P = 0.005). The sustained virological response (SVR) to treatment in patients with genotype 6 was also significantly superior to that of patients with genotype 1 (75.7% vs 57.1%, P = 0.02). Multiple logistic regression analysis demonstrated that age of 55 years or less, genotypes of hepatitis C virus, liver biopsy staging and baseline hepatitis C virus RNA of 200 000 IU/mL or less were independent predictors for better SVR in this cohort. Conclusion: Patients with chronic hepatitis C genotype 6 respond better to pegylated interferon and ribavirin combination treatment than patients with genotype 1. |
| Databáze: | OpenAIRE |
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