Periocular skin hyperpigmentation in children treated with prostaglandin analogues
| Autor: | Deepak P. Edward, Mohammed Al-Zobidi, Soumya Hanafi, Rajiv Khandekar, Earl Randy Craven |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.drug_class Prostaglandin Glaucoma Dermoscopy Skin Pigmentation chemistry.chemical_compound Hyperpigmentation Surveys and Questionnaires Prostaglandins Synthetic medicine Humans Child business.industry Infant Cheek medicine.disease Dermatology eye diseases body regions Ophthalmology Cross-Sectional Studies medicine.anatomical_structure chemistry Child Preschool Skin hyperpigmentation Pediatrics Perinatology and Child Health Eyelid Diseases Female sense organs Eyelid Prostaglandin analogue medicine.symptom business |
| Zdroj: | Journal of American Association for Pediatric Ophthalmology and Strabismus. 19:49-53 |
| ISSN: | 1091-8531 |
| DOI: | 10.1016/j.jaapos.2014.10.018 |
| Popis: | Purpose To report periocular skin hyperpigmentation related to prostaglandin analogue (PGA) use in children with glaucoma. Methods This cross-sectional study examined children treated with PGA for at least 6 months between June 2013 and December 2013. The pigmentation scores of the upper eyelids, lower eyelids and cheek were recorded with a chromameter. Hyperpigmentation was defined as a positive difference in scores between the cheek and the upper/lower eyelid. The influence of age, baseline skin pigmentation, duration of PGA, type of PGA and mono- or multitherapy on hyperpigmentation were evaluated. Subjective grading of pigmentation on standardized face photographs and the parent's perception of hyperpigmentation were also recorded. A P value of Result A total of 55 patients were included. Hyperpigmentation of the upper and lower eyelids occurred in all eyes. Subjectively, 26 (47%) eyes had mild and 14 (26%) moderate hyperpigmentation. The upper eyelid showed significantly greater hyperpigmentation than the lower eyelid ( P = 0.00004). Chromameter measurements overlapped with pigmentation grading on photographs. The type of and duration of PGA use, PGA mono- or multidrug therapy or baseline skin pigmentation had no effect on the grade of hyperpigmentation. Conclusions PGA use for more than 6 months was associated with periocular skin hyperpigmentation that was greater in the upper eyelid versus lower eyelid. All variables examined failed to show a relationship with the grade of hyperpigmentation. |
| Databáze: | OpenAIRE |
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