Selectivity of the photosensitiser Tookad® for photodynamic therapy evaluated in the Syrian golden hamster cheek pouch tumour model

Autor: A. Radu, Francois Borle, G. Wagnieres, H. van den Bergh, C. Fontolliet, Ph. Monnier
Jazyk: angličtina
Rok vydání: 2003
Předmět:
chemically induced squamous cell carcinoma
Male
Cancer Research
Pathology
medicine.medical_specialty
medicine.medical_treatment
9
10-Dimethyl-1
2-benzanthracene
Hamster
Photodynamic therapy
Biology
photosensitiser
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Cheek pouch
Cricetinae
medicine
Animals
Experimental Therapeutics
Bacteriochlorophylls
Mouth neoplasm
Photosensitizing Agents
Dose-Response Relationship
Drug
Mesocricetus
business.industry
Mouth Mucosa
Cheek
biology.organism_classification
3. Good health
pharmacodynamics
hamster tumour model
Dose–response relationship
medicine.anatomical_structure
Oncology
Epidermoid carcinoma
photodynamic therapy
Photochemotherapy
030220 oncology & carcinogenesis
Models
Animal
Carcinoma
Squamous Cell
Mouth Neoplasms
Nuclear medicine
business
9
10-Dimethyl-1
2-benzanthracene/adverse effects
Bacteriochlorophylls/administration & dosage
Carcinoma
Squamous Cell/chemically induced
Carcinoma
Squamous Cell/drug therapy
Mouth Mucosa/drug effects
Mouth Mucosa/radiation effects
Mouth Neoplasms/chemically induced
Mouth Neoplasms/drug therapy
Photosensitizing Agents/administration & dosage
Tookad®
palladium-bacteriopheophorbide
Zdroj: British Journal of Cancer
British journal of cancer, vol. 89, no. 12, pp. 2320-2326
ISSN: 1532-1827
0007-0920
Popis: The response to photodynamic therapy (PDT) with the photosensitiser (PS) Tookad was measured in the Syrian hamster cheek pouch model on normal mucosae and chemically induced squamous cell carcinoma. This PS is a palladium-bacteriopheophorbide presenting absorption peaks at 538 and 762 nm. The light dose, drug dose and drug injection-light irradiation times (DLI), ranging between 100 and 300 J cm(-2), 1-5 mg kg(-1) and 10-240 min respectively, were varied and the response to PDT was analysed by staging the macroscopic response and by the histological examination of the sections of the irradiated cheek pouch. A fast time decay of the tissular response with drug dose of 1-5 mg kg(-1) was observed for DLI ranging from 10 to 240 min and for light doses of 100-300 J cm(-2) delivered at a light dose rate of 150 mW cm(-2). A significantly higher level of tissular response was observed for squamous cell carcinoma compared to normal tissue. Nevertheless, the threshold level of the drug-light dose for a detectable response was not significantly different in the tumoral vs normal tissue. The highest response at the shortest DLIs and the absence of measurable response at DLI larger than 240 min at light dose of 300 J cm(-2) and drug dose of 5 mg kg(-1) reveals the predominantly vascular effect of Tookad. This observation suggests that Tookad could be effective in PDT of vascularised lesions.
Databáze: OpenAIRE
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