Clinical presentation of spontaneous primary hypothyroidism in adults
| Autor: | Talal Karima, Mahmoud Bagshi, Gady Magbool, Emmanuel Larbi, Ali Ibrahim Al-Sultan |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pediatrics
medicine.medical_specialty Adult patients business.industry education Primary hypothyroidism 030209 endocrinology & metabolism Retrospective cohort study General Medicine eye diseases 03 medical and health sciences 0302 clinical medicine parasitic diseases Medicine sense organs 030212 general & internal medicine Presentation (obstetrics) business geographic locations |
| Zdroj: | Annals of Saudi medicine. 15(2) |
| ISSN: | 0256-4947 |
| Popis: | In a retrospective study of 309 cases of hypothyroidism seen at King Fahd Hospital of the University (KFHU), Al-Khobar, 124 (90 Saudis and 34 non-Saudis) adult patients with spontaneous primary hypothyroidism satisfied the inclusion criteria for detailed analysis. Their male:female ratios for Saudis and non-Saudis were 1:4.6 and 1:3.9 respectively. The majority were diagnosed in their third and fourth decades. The prevalence of previously undiagnosed spontaneous and biochemically overt primary hypothyroidism in Saudis was 5.2/1000 females and 0.94/1000 males. FT4I was normal in 43 (35%) and low in 81 (65%). FT4I correlated with cold intolerance, constipation, dry skin, hoarseness, delayed reflex relaxation, and coarse and cold skin. In rank order, presenting symptoms in those with low FT4I were tiredness (56%), cold intolerance (38%), constipation, weight gain, menstrual disturbance - especially amenorrhea - (36% each), dry skin (35%), hoarseness (31%); signs were coarse skin (53%), delayed reflex relaxation (32%), cold skin and goiter (24% each). The above clinical findings may help physicians in the early detection of primary hypothyroidism. Population-based studies are necessary to provide more data on this disease in this country. |
| Databáze: | OpenAIRE |
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