Metabolism of Lactate in Alloxan Diabetic Acidosis
| Autor: | Edward J Barron, William J Steenrod, James W. Prahl |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
medicine.medical_specialty
Diabetic ketoacidosis Diabetic rat Endocrinology Diabetes and Metabolism Urine Diabetes Mellitus Experimental Diabetic Ketoacidosis Excretion chemistry.chemical_compound Internal medicine Alloxan Internal Medicine medicine Animals Carbon Isotopes Chemistry Cholesterol Fatty Acids Metabolism medicine.disease Lipids Liver Glycogen Rats Endocrinology DIABETIC ACIDOSIS Lactates |
| Zdroj: | Diabetes. 15:423-429 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/diab.15.6.423 |
| Popis: | Normal and alloxan diabetic rats were injected with DL-lactate-l-C-14, DL-lactate-2-C-14 and L(+) lactate-l-C-14 and the total excretion of radioactivity determined. The uncontrolled diabetic rat expired about 15–20 per cent less C-14-O2 than the normal animals. The diabetic animals excreted about twice as much radioactivity in the urine as the normal animals; in these diabetic animals essentially all of the radioactivity was found in glucose. After evaluation of all the possible reasons for the difference in amount of C-14-O2 expired by normal and diabetic animals it was concluded that lactate is metabolized at essentially the same rate in both animals but that in the diabetic animal, a greater portion of the carbon atoms of lactate is incorporated into glucose and less converted to CO2. |
| Databáze: | OpenAIRE |
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