Effects of repeated 9 and 30-day exposure to extremely low-frequency electromagnetic fields on social recognition behavior and estrogen receptors expression in olfactory bulb of Wistar female rats
| Autor: | Octavio Fabián Mercado-Gómez, Virginia Arriaga-Ávila, Rosalinda Guevara-Guzmán, Eduardo Martínez-Abundis, B Barrera-Mera, C Bernal-Mondragón |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Time Factors Ovariectomy Estrogen receptor Biology 03 medical and health sciences Electromagnetic Fields 0302 clinical medicine Western blot Internal medicine medicine Animals Rats Wistar Social Behavior Receptor Regulation of gene expression Analysis of Variance Estradiol medicine.diagnostic_test Dose-Response Relationship Radiation Recognition Psychology General Medicine Olfactory Bulb Rats Olfactory bulb Disease Models Animal 030104 developmental biology Endocrinology Gene Expression Regulation Receptors Estrogen Neurology Ovariectomized rat Immunohistochemistry Female Neurology (clinical) Analysis of variance Locomotion hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | Neurological Research. 39:165-175 |
| ISSN: | 1743-1328 0161-6412 |
| Popis: | We investigated the short- and long-term effects of extremely low-frequency electromagnetic fields (EMF) on social recognition behavior and expression of α- and β-estrogen receptors (ER).Rats were exposed to 60-Hz electromagnetic fields for 9 or 30 days and tested for social recognition behavior. Immunohistochemistry and western blot assays were performed to evaluate α- and β-ER expression in the olfactory bulb of intact, ovariectomized (OVX), and ovariectomized+estradiol (E2) replacement (OVX+E2).Ovariectomization showed impairment of social recognition after 9 days of EMF exposure and a complete recovery after E2 replacement and so did those after 30 days. Short EMF exposure increased expression of β-ER in intact, but not in the others. Longer exposure produced a decrease in intact but an increase in OVX and OVX+E2.Our findings suggest a significant role for β-estrogen receptors and a lack of effect for α-estrogen receptors on a social recognition task.EMF: extremely low frequency electromagnetic fields; ERs: estrogen receptors; OB: olfactory bulb; OVX: ovariectomized; OVX + E |
| Databáze: | OpenAIRE |
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