Connections of nutritional status and proton pump inhibitor therapy in patients scheduled for cardiovascular rehabilitation after treatment for ischemic and valvular heart disease
Autor: | Marinko Zulj, Aleksandar Včev, Viktor Peršić, Bojan Biocina, Vesna Pehar-Pejcnovic, Mate Petricevic, Marko Boban, Tomislav Sipic, Sanja Balen |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Adult
Male medicine.medical_specialty Malabsorption Heart Valve Diseases Logistic regression ischaemic heart disease Young Adult Internal medicine medicine Humans Young adult Renal Insufficiency Chronic BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine Aged Retrospective Studies Aged 80 and over BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina Cardiac Rehabilitation business.industry valvular heart disease Area under the curve Retrospective cohort study Proton Pump Inhibitors Middle Aged medicine.disease Confidence interval Surgery nutritional status schemic heart disease nutritional risk proton pump inhibitors (PPI) Female Cardiology and Cardiovascular Medicine business Kidney disease |
Zdroj: | Kardiologia Polska Volume 74 Issue 5 |
ISSN: | 0022-9032 |
Popis: | Background: Multiple and yet uncertain connections exist between cardiovascular diseases and the nutritional status of patients, particularly in relation to cardiovascular treatments. Proton pump inhibitors (PPI) are among the most commonly used group of drugs. Aim: To analyse utilisation of PPI in association with nutritional risk of patients scheduled for rehabilitation after treatment for ischaemic and valvular heart disease. Methods: Retrospective analyses on a consecutive sample of patients, which included drug utilisation of PPI and nutritional risk screening, using a standardised NRS-2002 tool. The patients (n = 536) were divided into groups based on previous cardiovascular treatments and use of PPI. Results: Nearly half of the patients (244, 46.1%) had PPI in their chronic therapy despite the clinically negligible prevalence of conditions that are their fundamental indications. The odds for using PPI in patients with increased nutritional risk, estimated by logistic regression, were 3.34 (95% confidence intervals [CI] 2.26–4.94), p < 0.001. Receiver operating curve analyses also revealed significant differences of PPI utilisation in connection with NRS-2002 > 3: positive likelihood-ratio (LR) 2.35 (95% CI 2.10–2.60); negative LR 0.46 (95% CI 0.4–0.6); area under the curve (AUC) 0.720; p < 0.001; as well as the percentage weigh loss history > 6.36% (positive LR 2.22 [95% CI 2.00–2.50]; negative LR 0.41 [95% CI 0.30–0.50]; AUC 0.707; p < 0.001). Conclusions: Utilisation of PPI was found to be of relatively high prevalence and significantly associated with parameters of nutritional risk screening. Furthermore, it was in correlation with the age of patients and the existence of chronic kidney dis - ease, which are well-established predispositions for poor nutritional status. Nutritional risk seems to be additionally negatively challenged by utilisation of PPI due to gastric malabsorption and anaemia. |
Databáze: | OpenAIRE |
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