Chemotherapeutic Activity of Combinations of Sulfisoxazole and Oleandomycin

Autor:	E. Grunberg, David J. Eldridge, E. Titsworth, W. F. DeLorenzo
Rok vydání:	1957
Předmět:	Sulfonamides Oleandomycin Chemistry Sulfisoxazole Pharmacology medicine.disease General Biochemistry Genetics and Molecular Biology In vitro Anti-Bacterial Agents Salmonella schottmuelleri Pneumococcal infections In vivo medicine Antibiotics Antitubercular medicine.drug
Zdroj:	Experimental Biology and Medicine. 95:144-147
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-95-23147
Popis:	Summary(1) In vitro under the specific conditions of the gradient plate technic, combinations of sulfisoxazole and oleandomycin in specific ratios show an activity superior to that observed with the single constituents. (2) Supplemental activity was also observed in vivo in the streptococcal, staphylococcal and pneumococcal infections when the ratio of the combination of sulfisoxazole to oleandomycin was 5 to 1. (3) The same type of effect was also observed in Salmonella schottmuelleri infection of mice when activity of sulfisoxazole was determined in a constant, inactive amount of oleandomycin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae4ab1db217038437c94603cc94ad5b https://doi.org/10.3181/00379727-95-23147 Zobrazit plný text záznamu