Preparation of a 7-Arylthieno[3,2-d]pyrimidin-4-Amine Library

Autor:	Yuanwei Chen, Dahong Jiang, Wenqing Lin, Shixue Yuan, Jinsong Peng
Rok vydání:	2007
Předmět:	Formamide chemistry.chemical_compound Pyrimidines Molecular Structure Suzuki reaction chemistry Combinatorial Chemistry Techniques Organic chemistry Stereoisomerism Amine gas treating General Medicine General Chemistry Combinatorial chemistry
Zdroj:	Journal of Combinatorial Chemistry. 9:431-436
ISSN:	1520-4774 1520-4766
DOI:	10.1021/cc0601534
Popis:	A focused kinase library of 7-arylthieno[3,2-d]pyrimidin-4-amine analogues is readily prepared via solution-phase parallel synthesis. This strategy relies on a key cyclization of a 3-aminothiophene-2-carboxamide with a formamide to construct the thienopyrimidine core. Further elaborations of this core via substitution and Suzuki coupling reactions allow the introduction of other diversity points. This methodology is demonstrated through the preparation of a 72-membered library of 7-arylthieno[3,2-d]pyrimidin-4-amines in good yields and high purities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae1e973d3fcce8a79f970e987568ab2 https://doi.org/10.1021/cc0601534 Zobrazit plný text záznamu