The HBx and HBc of hepatitis B virus can influence Id1 and Id3 by reducing their transcription and stability
| Autor: | Lulu Xia, Ailong Huang, Junye Liu, Jie Wei, Deqiang Wang, Shilie Wang, Hongpeng Zhang, Miao Luo, Yuan Yang, Yueyuan Shi, Chunhong Zou |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Inhibitor of Differentiation Protein 1
Male Cancer Research Hepatitis B virus Transcription Genetic viruses SMAD Biology medicine.disease_cause Virus 03 medical and health sciences Transcription (biology) Virology Cell Line Tumor medicine Animals Humans Viral Regulatory and Accessory Proteins 030304 developmental biology 0303 health sciences 030306 microbiology virus diseases Hep G2 Cells medicine.disease Molecular biology digestive system diseases Neoplasm Proteins Mice Inbred C57BL HBx Infectious Diseases Hepatocellular carcinoma Host-Pathogen Interactions Trans-Activators Inhibitor of Differentiation Proteins Signal transduction Hepatitis C Antigens Liver cancer |
| Zdroj: | Virus research. 284 |
| ISSN: | 1872-7492 |
| Popis: | Hepatitis B virus (HBV) infection is closely related with the occurrence and development of hepatocellular carcinoma (HCC), in which Hepatitis B virus x protein (HBx) and core protein (HBc) play crucial roles. Additionally, inhibitors of differentiation (Id) proteins exhibited significant correlation with liver cancer development. Here, we identified that HBV dramatically inhibited the expression of Id1 and Id3 in both protein and transcriptional levels for the first time, whereas there was little effect of the virus on Id2. Additionally, two HBV coded protein, HBc and HBx, could reduce the expression of Id1 and Id3 distinctly, whereas the other two viral proteins, HBs and HBp were unable to affect Id1 and Id3 proteins. Both the activity inhibitors and activators further confirmed that HBc inhibited the expression of Id1 and Id3 by BMP/Smad signaling pathway. HBx could interact with both Id1 and Id3 at residues 112-136 of HBx protein, and it could inhibit the two Id proteins by accelerating their degradation. This is the first report about HBc and HBx regulating Id1 and Id3, whereas the detailed mechanism associated with above needed further experiments to clarify. |
| Databáze: | OpenAIRE |
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