Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel
| Autor: | R, Ben-Ami, G, Rahav, H, Elinav, I, Kassis, I, Shalit, T, Gottesman, O, Megged, M, Weinberger, P, Ciobotaro, P, Shitrit, G, Weber, A, Paz, D, Miron, I, Oren, J, Bishara, C, Block, N, Keller, D P, Kontoyiannis, M, Giladi, Soboh, Soboh |
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| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Antifungal Adult Male medicine.medical_specialty Antifungal Agents medicine.drug_class Candida glabrata Drug resistance Candidaemia Drug Resistance Fungal Bloodstream infection Internal medicine Candida krusei Epidemiology Prevalence Medicine Humans Prospective Studies Israel Intensive care medicine Fluconazole Aged Candida Cross Infection drug resistance biology business.industry Candidemia General Medicine Middle Aged biology.organism_classification Hospitals Infectious Diseases Fluconazole resistant epidemiology Female business medicine.drug |
| Zdroj: | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 19(8) |
| ISSN: | 1469-0691 |
| Popis: | The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting. |
| Databáze: | OpenAIRE |
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