Accelerated Failure Time Survival Model to Analyze Morris Water Maze Latency Data
| Autor: | Bridget E. Hawkins, Clark R. Andersen, Donald S. Prough, Jordan Wolf, Kristofer Jennings |
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| Rok vydání: | 2021 |
| Předmět: |
Male
030506 rehabilitation medicine.medical_specialty Traumatic brain injury Morris water navigation task Accelerated failure time model survival analysis Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Morris Water Maze Test Brain Injuries Traumatic medicine Animals Latency (engineering) Memory testing latency Survival analysis Spatial Memory Cerebral Cortex business.industry traumatic brain injury Cognition Original Articles medicine.disease Rats Disease Models Animal Neurology (clinical) learning and memory 0305 other medical science business Morris water maze 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma |
| ISSN: | 1557-9042 0897-7151 |
| Popis: | Traumatic brain injury (TBI) induces cognitive deficits clinically and in animal models. Learning and memory testing is critical when evaluating potential therapeutic strategies and treatments to manage the effects of TBI. We evaluated three data analysis methods for the Morris water maze (MWM), a learning and memory assessment widely used in the neurotrauma field, to determine which statistical tool is optimal for MWM data. Hidden platform spatial MWM data aggregated from three separate experiments from the same laboratory were analyzed using 1) a logistic regression model, 2) an analysis of variance (ANOVA) model, and 3) an accelerated failure time (AFT) time-to-event model. The logistic regression model showed no significant evidence of differences between treatments among any swims over all days of the study, p > 0.11. Although the ANOVA model found significant evidence of differences between sham and TBI groups on three out of four swims on the third day, results are potentially biased due to the failure of this model to account for censoring. The time-to-event AFT model showed significant differences between sham and TBI over all swims on the third day, p |
| Databáze: | OpenAIRE |
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