Serum galectin-3 level predicts early recurrence following successful direct-current cardioversion in persistent atrial fibrillation patients
| Autor: | Muhammed Ulvi Yalcin, Hikmet Yorgun, Duygu Kocyigit, Kudret Aytemir, Ahmet Hakan Ateş, Kadri Murat Gurses, Hande Canpinar, Uğur Canpolat, Dicle Guc |
|---|---|
| Přispěvatelé: | Selçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Yalçın, Muhammed Ulvi |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
030213 general clinical medicine medicine.medical_specialty lcsh:Internal medicine lcsh:Diseases of the circulatory (Cardiovascular) system Turkey Cardiac fibrosis Galectin 3 Galectins medicine.medical_treatment Electric Countershock lcsh:Medicine 030204 cardiovascular system & hematology Cardioversion Disease-Free Survival 03 medical and health sciences electrical cardioversion galectin-3 remodeling 0302 clinical medicine Predictive Value of Tests Recurrence Internal medicine medicine Humans lcsh:RC31-1245 business.industry Hazard ratio lcsh:R Atrial fibrillation Blood Proteins Middle Aged medicine.disease Confidence interval Galectin-3 lcsh:RC666-701 Predictive value of tests Direct current cardioversion Cardiology Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Türk Kardiyoloji Derneği Arşivi, Vol 47, Iss 7, Pp 564-571 (2019) |
| Popis: | WOS: 000488637800004 PubMed: 31582678 Objective: Atrial structural remodeling has been suggested to contribute to atrial fibrillation (AF) recurrence following direct-current cardioversion (DCCV). The role of several inflammatory and extracellular matrix turnover markers in AF recurrence following DCCV has been investigated. However, data on the impact of galectin-3, which is known to play a role in various fibrotic conditions, including cardiac fibrosis are lacking. The aim of this study was to demonstrate the predictive role of serum galectin-3 levels in AF recurrence following successful DCCV. Methods: A total of 90 persistent AF patients who were scheduled for DCCV were prospectively enrolled. Serum samples were assayed to determine pre-DCCV galectin-3 levels using the enzyme-linked immunosorbent assay method. Patients were followed up for 3 months for AF recurrence. Results: Of 90 persistent AF patients (mean age: 55.33 +/- 7.94 years; 53.33% male) who underwent successful DCCV, 28 (31.11%) experienced early AF recurrence within 3 months. Patients with AF recurrence had a greater left atrial volume index (LAVI) (33.35 +/- 2.45 mL/m(2) vs. 29.21 +/- 3.08 mL/m(2); p Hacettepe University Scientific Research Projects Coordination UnitHacettepe University [1993] This project was funded by Hacettepe University Scientific Research Projects Coordination Unit (project number: 1993). |
| Databáze: | OpenAIRE |
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