NICOTONIC ACID BIOSYNTHESIS: CONTROL BY AN ENZYME THAT COMPETES WITH A SPONTANEOUS REACTION
| Autor: | Kunihiko Yano, Alan H. Mehler, Everette L. May |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Stereochemistry
Carboxy-Lyases Manometry Pyridines Niacin Diabetes Mellitus Experimental chemistry.chemical_compound Adenosine Triphosphate Anthranilic acid Animals Nucleotide ortho-Aminobenzoates Carbon Radioisotopes chemistry.chemical_classification Pharmacology Carbon Isotopes Multidisciplinary Research Nicotinic Acids Metabolism Carbon Dioxide Pyruvate carboxylase Rats Diphosphates Enzyme Nicotinic agonist chemistry Biochemistry Liver Liver Extracts Oxidoreductases Quinolinic acid |
| Zdroj: | Science (New York, N.Y.). 145(3634) |
| ISSN: | 0036-8075 |
| Popis: | Extracts of livers from diabetic rats contain normal amounts of the enzymes needed to convert 3-hydroxyanthranilic acid to nicotinic acid nucleotide. The decreased capacity of diabetic animals to synthesize nicotinic acid is therefore attributed to increased amounts of picolinic carboxylase, which competes for a common intermediate with the spontaneous reaction in which quinolinic acid is formed as a precursor of nicotinic acid. These studies were facilitated by the synthesis of 3-hydroxyanthranilic acid labeled with carbon-14 in positions 3 and 6 |
| Databáze: | OpenAIRE |
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