Antibacterial approaches in tissue engineering using metal ions and nanoparticles: From mechanisms to applications
| Autor: | Ulrich Eckhard, Mireia Hoyos-Nogués, Roman A. Perez, Maria Godoy-Gallardo, F. Javier Gil, Luis Delgado, Yolanda Puente |
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| Přispěvatelé: | Generalitat de Catalunya, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Enfermedades bacterianas
Nanoparticle 02 engineering and technology Bacteris Nanomaterials Regeneración (Biología) Tissue engineering Metal ions Biology (General) Materials of engineering and construction. Mechanics of materials chemistry.chemical_classification Biomoléculas Nanopartícules Chemistry Ions metàl·lics Nanopartículas Resistencia a los medicamentos 021001 nanoscience & nanotechnology Antimicrobial Tissues Regeneration (Biology) Materials biomèdics visual_art visual_art.visual_art_medium TA401-492 0210 nano-technology Antibacterial activity Bacterias Biotechnology Materiales biomédicos QH301-705.5 Metal ions in aqueous solution 0206 medical engineering Bacterial diseases Biomedical Engineering Metal nanoparticles Nanotechnology Teixits Iones metálicos Iones Mechanism of action Article Biomaterials Metal Biomolècules Resistència als medicaments Ions Biomolecules Malalties bacterianes Bacteria Regeneració (Biologia) Biomolecule 020601 biomedical engineering Tejidos Biomaterials applications Drug resistance Nanoparticles Biomedical materials |
| Zdroj: | Bioactive Materials, Vol 6, Iss 12, Pp 4470-4490 (2021) Bioactive Materials |
| Popis: | © 2021 The Authors. Bacterial infection of implanted scaffolds may have fatal consequences and, in combination with the emergence of multidrug bacterial resistance, the development of advanced antibacterial biomaterials and constructs is of great interest. Since decades ago, metals and their ions had been used to minimize bacterial infection risk and, more recently, metal-based nanomaterials, with improved antimicrobial properties, have been advocated as a novel and tunable alternative. A comprehensive review is provided on how metal ions and ion nanoparticles have the potential to decrease or eliminate unwanted bacteria. Antibacterial mechanisms such as oxidative stress induction, ion release and disruption of biomolecules are currently well accepted. However, the exact antimicrobial mechanisms of the discussed metal compounds remain poorly understood. The combination of different metal ions and surface decorations of nanoparticles will lead to synergistic effects and improved microbial killing, and allow to mitigate potential side effects to the host. Starting with a general overview of antibacterial mechanisms, we subsequently focus on specific metal ions such as silver, zinc, copper, iron and gold, and outline their distinct modes of action. Finally, we discuss the use of these metal ions and nanoparticles in tissue engineering to prevent implant failure. M.G-G and U.E have received funding from the postdoctoral fellowship programme Beatriu de Pinós, funded by the Secretary of Universities and Research (Government of Catalonia) and by the Horizon 2020 programme of research and innovation of the European Union under the Marie Sklodowska-Curie grant agreement No 801370. R.A.P is supported by the Spanish Ministry by the Ramón y Cajal Program (RYC2018-025977-I). Additional financial support was provided by the Government of Catalonia (2017 SGR 708) and MINECO/FEDER project (RTI2018-096088-J-100). |
| Databáze: | OpenAIRE |
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