Acute liver failure in children—Is living donor liver transplantation justified?
Autor: | Małgorzata Markiewicz-Kijewska, Marek Szymczak, Piotr Kaliciński, Joanna Teisseyre, Waldemar Patkowski, Irena Jankowska, Dorota Broniszczak, Hor Ismail, Grzegorz Kowalewski, Adam Kowalski, Marek Stefanowicz |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Male
medicine.medical_treatment lcsh:Medicine Kaplan-Meier Estimate 030230 surgery Liver transplantation Pediatrics 0302 clinical medicine Transplant surgery Pediatric Surgery Postoperative Complications Hypothermia Induced Pediatric surgery Medicine and Health Sciences Living Donors Medicine Young adult lcsh:Science Child Pathology and laboratory medicine Multidisciplinary Liver Diseases Graft Survival Living-Related Liver Transplantation Medical microbiology Middle Aged Treatment Outcome Child Preschool Viruses Retreatment 030211 gastroenterology & hepatology Female Pathogens Living donor liver transplantation Research Article Adult medicine.medical_specialty Hepatitis B virus Adolescent Surgical and Invasive Medical Procedures Gastroenterology and Hepatology Microbiology Time-to-Treatment 03 medical and health sciences Digestive System Procedures Young Adult Humans Retrospective Studies Transplantation Biology and life sciences business.industry lcsh:R Liver failure Viral pathogens Organisms Infant Retrospective cohort study Organ Transplantation Liver Failure Acute Hepatitis viruses Surgery Liver Transplantation Microbial pathogens lcsh:Q business Follow-Up Studies |
Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 2, p e0193327 (2018) |
ISSN: | 1932-6203 |
Popis: | Objectives Living donor liver transplantation (LDLT) in patients with acute liver failure (ALF) has become an acceptable alternative to transplantation from deceased donors (DDLT). The aim of this study was to analyze outcomes of LDLT in pediatric patients with ALF based on our center’s experience. Material and methods We enrolled 63 children (at our institution) with ALF who underwent liver transplantation between 1997 and 2016. Among them 24 (38%) underwent a LDLT and 39 (62%) received a DDLT. Retrospectively analyzed patient clinical data included: time lapse between qualification for transplantation and transplant surgery, graft characteristics, postoperative complications, long-term results post-transplantation, and living donor morbidity. Overall, we have made a comparison of clinical results between LDLT and DDLT groups. Results Follow-up periods ranged from 12 to 182 months (median 109 months) for LDLT patients and 12 to 183 months (median 72 months) for DDLT patients. The median waiting time for a transplant was shorter in LDLT group than in DDLT group. There was not a single case of primary non-function (PNF) in the LDLT group and 20 out of 24 patients (83.3%) had good early graft function; 3 patients (12.5%) in the LDLT group died within 2 months of transplantation but there was no late mortality. In comparison, 4 out of 39 patients (10.2%) had PNF in DDLT group while 20 patients (51.2%) had good early graft function; 8 patients (20.5%) died early within 2 months and 2 patients (5.1%) died late after transplantation. The LDLT group had a shorter cold ischemia time (CIT) of 4 hours in comparison to 9.2 hours in the DDLT group (p |
Databáze: | OpenAIRE |
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