Acute liver failure in children—Is living donor liver transplantation justified?

Autor: Małgorzata Markiewicz-Kijewska, Marek Szymczak, Piotr Kaliciński, Joanna Teisseyre, Waldemar Patkowski, Irena Jankowska, Dorota Broniszczak, Hor Ismail, Grzegorz Kowalewski, Adam Kowalski, Marek Stefanowicz
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
medicine.medical_treatment
lcsh:Medicine
Kaplan-Meier Estimate
030230 surgery
Liver transplantation
Pediatrics
0302 clinical medicine
Transplant surgery
Pediatric Surgery
Postoperative Complications
Hypothermia
Induced
Pediatric surgery
Medicine and Health Sciences
Living Donors
Medicine
Young adult
lcsh:Science
Child
Pathology and laboratory medicine
Multidisciplinary
Liver Diseases
Graft Survival
Living-Related Liver Transplantation
Medical microbiology
Middle Aged
Treatment Outcome
Child
Preschool
Viruses
Retreatment
030211 gastroenterology & hepatology
Female
Pathogens
Living donor liver transplantation
Research Article
Adult
medicine.medical_specialty
Hepatitis B virus
Adolescent
Surgical and Invasive Medical Procedures
Gastroenterology and Hepatology
Microbiology
Time-to-Treatment
03 medical and health sciences
Digestive System Procedures
Young Adult
Humans
Retrospective Studies
Transplantation
Biology and life sciences
business.industry
lcsh:R
Liver failure
Viral pathogens
Organisms
Infant
Retrospective cohort study
Organ Transplantation
Liver Failure
Acute
Hepatitis viruses
Surgery
Liver Transplantation
Microbial pathogens
lcsh:Q
business
Follow-Up Studies
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0193327 (2018)
ISSN: 1932-6203
Popis: Objectives Living donor liver transplantation (LDLT) in patients with acute liver failure (ALF) has become an acceptable alternative to transplantation from deceased donors (DDLT). The aim of this study was to analyze outcomes of LDLT in pediatric patients with ALF based on our center’s experience. Material and methods We enrolled 63 children (at our institution) with ALF who underwent liver transplantation between 1997 and 2016. Among them 24 (38%) underwent a LDLT and 39 (62%) received a DDLT. Retrospectively analyzed patient clinical data included: time lapse between qualification for transplantation and transplant surgery, graft characteristics, postoperative complications, long-term results post-transplantation, and living donor morbidity. Overall, we have made a comparison of clinical results between LDLT and DDLT groups. Results Follow-up periods ranged from 12 to 182 months (median 109 months) for LDLT patients and 12 to 183 months (median 72 months) for DDLT patients. The median waiting time for a transplant was shorter in LDLT group than in DDLT group. There was not a single case of primary non-function (PNF) in the LDLT group and 20 out of 24 patients (83.3%) had good early graft function; 3 patients (12.5%) in the LDLT group died within 2 months of transplantation but there was no late mortality. In comparison, 4 out of 39 patients (10.2%) had PNF in DDLT group while 20 patients (51.2%) had good early graft function; 8 patients (20.5%) died early within 2 months and 2 patients (5.1%) died late after transplantation. The LDLT group had a shorter cold ischemia time (CIT) of 4 hours in comparison to 9.2 hours in the DDLT group (p
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje