Serum anti-glycan-antibodies in relatives of patients with inflammatory bowel disease
| Autor: | Gerhard Rogler, Florian Kamm, Frauke Degenhardt, Andre Franke, Ulrike Strauch, Rocio Lopez, Claudia Kunst, Florian Rieders, Frank Klebl |
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| Přispěvatelé: | University of Zurich, Rieders, Florian |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Physiology Gene Expression lcsh:Medicine Crohn's Disease Pathology and Laboratory Medicine Inflammatory bowel disease Biochemistry Serology 0302 clinical medicine Immune Physiology Medicine and Health Sciences Medicine Family history Enzyme-Linked Immunoassays lcsh:Science Immune Response Crohn's disease Multidisciplinary Immune System Proteins biology Organic Compounds Middle Aged Colitis Ulcerative colitis Chemistry 10219 Clinic for Gastroenterology and Hepatology 030220 oncology & carcinogenesis Physical Sciences 030211 gastroenterology & hepatology Female Antibody Research Article Adult Immunology Carbohydrates Enzyme-Linked Immunosorbent Assay 610 Medicine & health Gastroenterology and Hepatology 1100 General Agricultural and Biological Sciences Research and Analysis Methods Antibodies Autoimmune Diseases 03 medical and health sciences Young Adult Immune system Antigen Polysaccharides 1300 General Biochemistry Genetics and Molecular Biology Humans Ulcerative Colitis Immunoassays Autoantibodies 1000 Multidisciplinary business.industry lcsh:R Inflammatory Bowel Disease Organic Chemistry Chemical Compounds Biology and Life Sciences Proteins medicine.disease Inflammatory Bowel Diseases biology.protein Immunologic Techniques lcsh:Q Clinical Immunology Clinical Medicine business Biomarkers |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 3, p e0194222 (2018) |
| Popis: | BACKGROUND Serum anti-glycan antibodies are a promising tool for differential diagnosis, disease stratification and prediction of Crohn's disease (CD). To investigate possible heritability of the markers we assessed the presence of serum anti-glycan antibodies in affected and unaffected relatives of patients with CD. METHODS Serum samples of 169 IBD patients of the German inflammatory bowel disease (IBD) network (140 CD & 29 Ulcerative colitis (UC)), 349 relatives of CD patients, 63 relatives of UC patients and 46 healthy controls were tested for the presence of anti-glycan antibodies by ELISA in a blinded fashion. Clinical data of the IBD patients and controls were available. RESULTS A higher proportion of non-affected CD relatives was positive for anti-glycan antibodies compared to healthy subjects. No inheritance of a specific pattern of anti-glycan antibodies could be detected. No difference in marker expression depending on the degree of relationship in the non-affected relatives was noted and the presence of family history did not lead to a difference in marker levels in the affected CD subjects. CONCLUSIONS Non-affected CD relatives had a higher frequency of anti-glycan antibodies compared to healthy subjects. This difference was mild and was found to be true for the overall reactivity to glycan antigens, but not for specific patterns. This may indicate an inherited mechanism resulting in a non-specific increased reactivity to microbial antigens in IBD. |
| Databáze: | OpenAIRE |
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