Synchronous occurrence of neuroendocrine colon carcinoma and hairy cell leukemia
| Autor: | Dimitrios Sambaziotis, Evangelos Tsiambas, Christos Gakis, Nikolaos S. Salemis, Charalambos Christofyllakis, Dionisios Pinialidis, Georgios Nakos |
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| Rok vydání: | 2010 |
| Předmět: |
Oncology
Male medicine.medical_specialty Pathology Colorectal cancer Population Rectum Neoplasms Multiple Primary Risk Factors hemic and lymphatic diseases Internal medicine Biopsy Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Hairy cell leukemia education Aged Neoplasm Staging education.field_of_study Leukemia Hairy Cell medicine.diagnostic_test business.industry Incidence Colonic Neoplasms/drug therapy/*pathology Leukemia Hairy Cell/drug therapy/*pathology Gastroenterology Carcinoma Neuroendocrine/drug therapy/*pathology Colonoscopy medicine.disease Pancytopenia Carcinoma Neuroendocrine Leukemia medicine.anatomical_structure Treatment Outcome Colonic Neoplasms Antineoplastic Combined Chemotherapy Protocols/therapeutic use business Tomography X-Ray Computed |
| Zdroj: | Journal of gastrointestinal cancer. 42(3) |
| ISSN: | 1941-6636 |
| Popis: | BACKGROUND-PURPOSE: The risk of secondary malignancy development in patients with hairy cell leukemia has been evaluated in several studies with varying results. The aim of this study is to describe a case of synchronous occurrence of neuroendocrine colon carcinoma and hairy cell leukemia. METHODS: A 69-year-old man presented with rectal bleeding. Colonoscopy revealed a rectal tumor, whereas biopsy specimens revealed a poorly differentiated carcinoma. During the preoperative evaluation, pancytopenia was detected. RESULTS: At laparotomy, a mass was detected 16 cm from the anal verge and an anterior resection of the rectum was performed. Detailed histological and immunohistochemical analyses revealed a poorly differentiated neuroendocrine carcinoma of the rectum. Postoperative evaluation of pancytopenia revealed hairy cell leukemia. The patient was initially treated with chemotherapy for hairy cell leukemia followed by chemotherapy for neuroendocrine colon carcinoma. Survival was 44 months. CONCLUSIONS: To our knowledge, synchronous occurrence of neuroendocrine colon carcinoma and hairy cell leukemia has not been previously reported in the literature. Given the rare incidence of both entities in the general population, it is highly unlikely that they occurred together by chance. Further research is needed to determine what would be the optimal management options of patients with simultaneous hairy cell leukemia and a neuroendocrine colon cancer. J Gastrointest Cancer |
| Databáze: | OpenAIRE |
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