Serum factors in the progression of human immunodeficiency virus type 1 infection to AIDS
| Autor: | Russell H. Tomar, P A John, M A R Yuille, A K Hennig, R P Oates |
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| Rok vydání: | 1990 |
| Předmět: |
Microbiology (medical)
Exacerbation T-Lymphocytes Clinical Biochemistry Enzyme-Linked Immunosorbent Assay HIV Infections Peripheral blood mononuclear cell Immune system Acquired immunodeficiency syndrome (AIDS) HIV Seropositivity medicine Immunology and Allergy Humans Receptor Antilymphocyte Serum Acquired Immunodeficiency Syndrome Lymphokines biology Biochemistry (medical) Public Health Environmental and Occupational Health Receptors Interleukin-2 Hematology medicine.disease Isotype Medical Laboratory Technology Immunology biology.protein HIV-1 Paraproteins Antibody Interleukin-1 |
| Zdroj: | Journal of clinical laboratory analysis. 4(3) |
| ISSN: | 0887-8013 |
| Popis: | We studied the prevalence of four serum factors in individuals at different stages of human immunodeficiency virus-1 (HIV-1) infection. Soluble interleukin-2 receptors (sIL-2R) were elevated in all antibody-positive groups compared with high-risk, antibody-negative controls. Paraproteins, usually of the IgG-kappa isotype, were found in the sera of a significant number of HIV-1-infected individuals as were antibodies to lymphocytes (ALAs). Serum factors that inhibit proliferation of peripheral blood mononuclear cells from healthy donors appear late in the course of infection and were associated with increasing clinical severity. Measurement of these factors may prove to be useful in defining the stages of infection and in predicting the appearance or exacerbation of symptoms. They may also play a role in the development of the HIV-1-induced immune defects that lead to the expression of clinical acquired immunodeficiency syndrome. |
| Databáze: | OpenAIRE |
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