Triumph and tumult of matrix metalloproteinases and their crosstalk with eicosanoids in cancer
| Autor: | Kasturi Chatterjee, Snehasikta Swarnakar, Preety Choudhary, Sayantan Jana |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Stromal cell Thromboxane Matrix metalloproteinase Proto-Oncogene Mas Metastasis Extracellular matrix 03 medical and health sciences 0302 clinical medicine Neoplasms Tumor Microenvironment medicine Animals Humans Tumor microenvironment Chemistry Lipid Metabolism medicine.disease Matrix Metalloproteinases Biosynthetic Pathways Extracellular Matrix Crosstalk (biology) 030104 developmental biology Oncology Eicosanoid 030220 oncology & carcinogenesis Cancer research Eicosanoids lipids (amino acids peptides and proteins) Signal Transduction |
| Zdroj: | Cancer and Metastasis Reviews. 37:279-288 |
| ISSN: | 1573-7233 0167-7659 |
| Popis: | Cancer development and metastasis are associated to perturbation in metabolic functions of tumor cells and surrounding inflammatory and stromal cell responses. Eicosanoids and lipid mediators, in this regard, attract potential attention during cancer development. Eicosanoids, which include prostaglandin, prostacyclin, thromboxane, and leukotriene, are synthesized from arachidonic acid when cells are stimulated by stress, cytokines, or other growth factors. However, the underlying mechanism of eicosanoids in cancer development, specially their interactions with proto-oncogene factors in tumor microenvironment, remain unexplored. On the other hand, matrix metalloproteinases (MMPs) are a group of zinc-dependent endopeptidases which are involved in degradation of different extracellular matrix (ECM) proteins. MMPs are associated with different physiological responses, including embryogenesis, vasculogenesis, and cellular remodeling, as well as different disease pathogenesis. Induced MMP responses are especially associated with cancer metastasis and secondary tumor development through proteolytic cleavage of several ECM and non-ECM proteins. Although both eicosanoids and MMPs are involved with cancer progression and metastasis, the interrelation between these two molecules are less explored. The present review discusses relevant studies that connect eicosanoids and MMPs and highlight the crosstalk between them offering novel therapeutic approach in cancer treatment. |
| Databáze: | OpenAIRE |
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