Uterine Neuroectodermal Tumor with Ependymoblastic Features in an Infant with Clonal +del (2)(q11.2),-13: A Possible Role of Increased Gene Dosage on 2pter-2q11.2 in the Tumorigenesis
| Autor: | Ludvik R. Donner |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty CD99 Gene Dosage Abnormal Karyotype Neuroectodermal Tumors Vimentin Hysterectomy Gene dosage Pathology and Forensic Medicine Fatal Outcome Antineoplastic Combined Chemotherapy Protocols medicine Humans Neuroectodermal tumor Chromosomes Human Pair 13 biology Infant General Medicine Nestin medicine.disease Combined Modality Therapy Immunohistochemistry Cell Transformation Neoplastic Chromosomes Human Pair 2 Uterine Neoplasms Pediatrics Perinatology and Child Health biology.protein Synaptophysin Female Medulloepithelioma Trisomy |
| Zdroj: | Pediatric and Developmental Pathology. 15:226-231 |
| ISSN: | 1615-5742 1093-5266 |
| Popis: | Clonal +(2)(q11.2),-13 was detected in a uterine neuroectodermal tumor with ependymoblastic features arising in an infant. The tumor expressed vimentin, nestin, CD56, CD99, microtubule-associated protein 1B (MAP 1B), focally microtubule-associated protein 2 (MAP 2), synaptophysin, neuron-specific enolase, and, very focally, epithelial membrane antigen. Because trisomy 2 was previously detected in a medulloepithelioma of pelvic soft tissue and in several neuroectodermal tumors of the central nervous system, this finding is indicative of a possible role of increased dosage of gene(s) on chromosome 2 in the tumorigenesis of these neoplasms and of their histogenetic relatedness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|