Comparison of efficacy, toxicity and pharmacokinetics of free adriamycin and adriamycin linked to oxidized dextran in rats
| Autor: | Kazumasa Yokoyama, Yoshiaki Kanoh, Koji Munechika, Yasuo Ueda, Kouichi Yamanouchi, Akihito Kikukawa |
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| Rok vydání: | 1989 |
| Předmět: |
Chemotherapy
Drug Carriers Chemistry medicine.medical_treatment Dextrans General Chemistry General Medicine Prodrug Pharmacology Acute toxicity Rats carbohydrates (lipids) chemistry.chemical_compound Therapeutic index Dextran Pharmacokinetics Doxorubicin Drug Discovery Toxicity polycyclic compounds medicine Animals Carcinoma 256 Walker medicine.drug |
| Zdroj: | Chemicalpharmaceutical bulletin. 37(6) |
| ISSN: | 0009-2363 |
| Popis: | Adriamycin linked to oxidized dextran (ADM-OXD) via Schiff's base formation was compared with free adriamycin with regard to antitumor activity, acute toxicity and plasma pharmacokinetics in rats following i.v. administration. ADM-OXD showed higher activity against Walker carcinosarcoma 256 than free adriamycin. On the other hand, the acute toxicity of ADM-OXD was about three times less than that of free adriamycin. In contrast to free adriamycin, a very high plasma level of adriamycin was found after i.v. administration of ADM-OXD. The area under the plasma concentration curve with ADM-OXD was about 160-fold higher than with free adriamycin. Thus, the improvement of the therapeutic index in the case of ADM-OXD might be due to the difference in the disposition of ADM-OXD and free adriamycin in rats. |
| Databáze: | OpenAIRE |
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