Astaxanthin n-Octanoic Acid Diester Ameliorates Insulin Resistance and Modulates Gut Microbiota in High-Fat and High-Sucrose Diet-Fed Mice

Autor: Yao Xian Chin, Lu Yang, Yuan Gao, Qingjuan Tang, Changhu Xue, Robert W. Li, Fang Liu, Jie Xu, Shihan Yuan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Sucrose
Gut flora
Xanthophylls
lcsh:Chemistry
chemistry.chemical_compound
Mice
0302 clinical medicine
fluids and secretions
astaxanthin n-octanoic acid diester
insulin resistance
lcsh:QH301-705.5
Spectroscopy
Phylogeny
biology
General Medicine
Computer Science Applications
Up-Regulation
Intestines
030220 oncology & carcinogenesis
medicine.symptom
medicine.medical_specialty
Inflammation
Carbohydrate metabolism
Diet
High-Fat
digestive system
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Insulin resistance
Nutraceutical
Astaxanthin
Internal medicine
Glucose Intolerance
medicine
High fat
Animals
Physical and Theoretical Chemistry
16S rRNA
Molecular Biology
Tight Junction Proteins
gut microbiota
Organic Chemistry
Feeding Behavior
medicine.disease
biology.organism_classification
Gastrointestinal Microbiome
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
lcsh:Biology (General)
lcsh:QD1-999
inflammation
Bacteroides
Zdroj: International Journal of Molecular Sciences
Volume 21
Issue 6
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2149 (2020)
ISSN: 1422-0067
DOI: 10.3390/ijms21062149
Popis: Astaxanthin n-octanoic acid diester (AOD) is a type of astaxanthin connecting medium-chain fatty acids with a more stable structure. In this study, we examined the role of AOD in ameliorating insulin resistance (IR) induced by a high-fat and high-sucrose diet (HFD) as well as its effect on modulating gut microbiota in mice, with free astaxanthin (AST) as a comparison. Four groups of male C57BL/6J mice (6 weeks old
n = 10 per group) were fed with a normal control diet (NC), HFD orally administered with AOD, AST (50 mg/kg body weight), or vehicle for 8 weeks. AOD improved glucose tolerance, IR, systematic and intestinal inflammation, and intestinal integrity better than AST. Further, both AOD and AST modulated gut microbiota. A significantly higher abundance of Bacteroides and Coprococcus was found in AOD than in AST, and the predicted pathway of carbohydrate metabolism was significantly impacted by AOD. Overall, AOD may play a role in alleviating IR and inflammation with the modulating effect on microbiota in HFD-fed mice. Our findings could facilitate the development of AOD as a bioactive nutraceutical and more stable alternative to AST.
Databáze: OpenAIRE
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