Effect of adrenergic blockade on dynamics of the pregnant primate uterus (Macaca mulatta)
| Autor: | Kenneth R. Spisso, Guy M. Harbert |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Adrenergic beta-Antagonists Uterus Propranolol Catecholamines Phentolamine Pregnancy Internal medicine Animals Medicine Circadian rhythm Adrenergic alpha-Antagonists Dose-Response Relationship Drug business.industry Hemodynamics Myometrium Obstetrics and Gynecology Blood flow Amniotic Fluid Macaca mulatta Circadian Rhythm Blockade medicine.anatomical_structure Endocrinology Vascular resistance Female business medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 139:767-780 |
| ISSN: | 0002-9378 |
| Popis: | Unanesthetized rhesus monkeys, conditioned to restraining chairs and monitored continuously by chronically implanted sensors, were used to explore the relationships between catecholamines and uterine dynamics during late gestation. Continuous intra-aortic infusion of phentolamine produced a dose-response decrease in uterine activity and blood flow. With alpha-adrenergic blockade the circadian (Fourier) variations of uterine activity were abolished and those of uterine blood flow were reversed. Placental blood flow (by the microsphere technique) was 86.1% of control values. Beta-adrenergic blockade (propranolol) accentuated the circadian variations of uterine dynamics. Vascular resistance to both the myometrium and the placentas was increased. The data indicate that the maternal placental vasculature is the primary site of uterine vascular resistance and is susceptible to adrenergic response. The data also suggest that the extrinsic resistance produced by the myometrium is of major importance in the distribution of uterine blood flow. |
| Databáze: | OpenAIRE |
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