Two-component models are of limited value for the assessment of body composition in patients with cirrhosis
| Autor: | G. Jennings, Marinos Elia, NJ Fuller, Marsha Y. Morgan, Angela Madden |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Cirrhosis Bone density Body water Medicine (miscellaneous) Renal function Models Biological Sensitivity and Specificity Absorptiometry Photon Body Water Bone Density Liver Cirrhosis Alcoholic Internal medicine Electric Impedance medicine Humans Deuterium Oxide Muscle Skeletal Dual-energy X-ray absorptiometry Aged Nutrition and Dietetics medicine.diagnostic_test business.industry Chemistry Body Weight Reproducibility of Results Middle Aged medicine.disease Body Height Endocrinology Adipose Tissue Case-Control Studies Creatinine Body Composition Lean body mass Female Densitometry Nuclear medicine business Bioelectrical impedance analysis Mathematics |
| Zdroj: | University of Hertfordshire Europe PubMed Central |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/84.5.1151 |
| Popis: | Background: Most techniques for measuring body composition are based on 2-component models (2-CMs) and depend on assumptions relating to the constancy of the density (D-FFM) and hydration fraction (HFFFM) of fat-free mass (FFM).Objectives: The objectives were to determine whether these assumptions are systematically violated in patients with cirrhosis and to assess the validity of the estimates of body composition obtained in these patients by using 2-CM techniques.Design: Body composition was assessed by using a 4-component model (4-CM), which was based on data obtained from densitometry, deuterium dilution, and dual-energy X-ray absorptiometry, in 20 patients with cirrhosis who had no evidence of fluid retention and in 20 pair-matched healthy control subjects. The results were compared with those obtained by using "reference" and "bedside" 2-CM techniques.Results: The mean (+/- SD) D-FFM was significantly lower in the patients with cirrhosis (1.091 +/- 0.008 compared with 1.100 +/- 0.006 kg/L; P < 0.001); no significant difference in HFFFM was observed between the patients and control subjects (74.5 +/- 2.6 compared with 73.5 +/- 2.1), although there was greater variability in the patients. Significant differences were observed in the body-composition variables obtained by using the "reference" 2-CM techniques compared with the 4-CM-the 95% limits of agreement in the patients with cirrhosis exceeded 5% body fat and 3 kg FFM; the corresponding values for the "bedside" 2-CM techniques were 11% body fat and 7.5 kg FFM.Conclusions: Assumptions relating to the constancy of the DFFM and HFFFM are violated in patients with cirrhosis. Thus, standard 2-CM techniques provide inaccurate body composition estimates in this patient population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|