Mast cells in neuroimmune function: Neurotoxicological and neuropharmacological perspectives
| Autor: | C.K. Atterwill, Wendy M. Purcell |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Neuroimmunomodulation
Models Neurological Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Neurotrophic factors Monoaminergic medicine Animals Humans Biogenic Monoamines Mast Cells Nerve Growth Factors Neuroinflammation Neurons biology business.industry Biogenic Polyamines General Medicine medicine.disease Mast cell medicine.anatomical_structure Nerve growth factor chemistry biology.protein Alzheimer's disease business Neuroscience Histamine Neurotrophin |
| Zdroj: | Neurochemical Research. 20:521-532 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/bf01694534 |
| Popis: | Mast cells are located in close proximity to neurons in the peripheral and central nervous systems, suggesting a functional role in normal and aberrant neurodegenerative states. They also possess many of the features of neurons, in terms of monoaminergic systems, responsiveness to neurotrophins and neuropeptides and the ability to synthesise and release bioactive neurotrophic factors. Mast cells are able to secrete an array of potent mediators which may orchestrate neuroinflammation and affect the integrity of the blood-brain barrier. The 'cross-talk' between mast cells, lymphocytes, neurons and glia constitutes a neuroimmune axis which is implicated in a range of neurodegenerative diseases with an inflammatory and/or autoimmune component, such as multiple sclerosis and Alzheimer's disease. Mast cells appear to make an important contribution to developing, mature and degenerating nervous systems and this should now be recognised when assessing the neurotoxic potential of xenobiotics. |
| Databáze: | OpenAIRE |
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