Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats

Autor: E Nandhakumar, H. Haseena Banu, R Sundaram
Rok vydání: 2019
Předmět:
Blood Glucose
Male
medicine.medical_specialty
Health
Toxicology and Mutagenesis
medicine.medical_treatment
010501 environmental sciences
Carbohydrate metabolism
Toxicology
01 natural sciences
Streptozocin
Diabetes Mellitus
Experimental
Eating
03 medical and health sciences
Glycogen phosphorylase
chemistry.chemical_compound
Hesperidin
Hexokinase
Internal medicine
Diabetes mellitus
medicine
Animals
Hypoglycemic Agents
Insulin
Rats
Wistar
Glycogen synthase
0105 earth and related environmental sciences
Glycated Hemoglobin
0303 health sciences
Dose-Response Relationship
Drug
biology
Glycogen
Chemistry
Body Weight
030302 biochemistry & molecular biology
Glucose Tolerance Test
medicine.disease
Streptozotocin
Fructose-Bisphosphatase
Endocrinology
Glucose-6-Phosphatase
biology.protein
Carbohydrate Metabolism
medicine.drug
Zdroj: Toxicology Mechanisms and Methods. 29:644-653
ISSN: 1537-6524
1537-6516
DOI: 10.1080/15376516.2019.1646370
Popis: The present study investigated the protective effect of hesperidin on carbohydrate metabolizing enzymes in streptozotocin-induced diabetic rats. Hesperidin was administered to streptozotocin-induced (40 mg/kg b.w.) diabetic rats at different dosages of (25, 50, 100 mg/kg b.w.) respectively for 30 days to evaluate its effect on fasting plasma glucose, insulin, glycosylated hemoglobin, hemoglobin, and carbohydrate metabolic enzymes. The plasma glucose levels were significantly reduced in a dose-dependent manner in hesperdin-treated group of rats when compared to the diabetic control rats. In addition, concomitant increase in hemoglobin and insulin levels and a decrease in glycosylated hemoglobin were observed in treated group of rats. The activities of the hepatic key enzymes of carbohydrate metabolism such as hexokinase and glucose-6-phosphate dehydrogenase were significantly increased, whereas glucose-6-phosphatase and fructose-1,6-bisphosphatase were significantly decreased. Furthermore, hesperidin administration prevented the loss in body weight and improved the glycogen content in the hepatic tissue of diabetic animals by reinstating the activities of glycogen synthase and glycogen phosphorylase. These results showed that hesperidin has potential antihyperglycemic activity in streptozotocin-induced diabetic rats. This was further supported by the histological studies of pancreas and liver.
Databáze: OpenAIRE
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