Relationship of plasma cholesteryl ester transfer protein to HDL cholesterol. Studies in normotriglyceridemia and moderate hypertriglyceridemia
| Autor: | Bernhard Föger, Alfred Doblinger, Holger Wessels, Josef R. Patsch, Andreas Ritsch |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty chemistry.chemical_compound Internal medicine Phospholipid transfer protein Cholesterylester transfer protein Blood plasma medicine Humans Triglycerides Aged Glycoproteins Hypertriglyceridemia Lipoprotein lipase biology Chemistry Cholesterol Cholesterol HDL nutritional and metabolic diseases Middle Aged medicine.disease Dietary Fats Cholesterol Ester Transfer Proteins carbohydrates (lipids) Lipoprotein Lipase Endocrinology Postprandial biology.protein lipids (amino acids peptides and proteins) Hepatic lipase Cholesterol Esters Cardiology and Cardiovascular Medicine Carrier Proteins |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology. 16(12) |
| ISSN: | 1079-5642 |
| Popis: | To evaluate the independent effect of cholesteryl ester transfer protein (CETP) on HDL concentrations in humans, we measured lipids, lipoproteins, postprandial lipemia after an oral fat load, CETP mass, and the activities of CETP, lipoprotein lipase (LPL), and hepatic lipase in 16 healthy, normotriglyceridemic men and in 23 men with moderate, primary hypertriglyceridemia on an American Heart Association Step I diet. Fasting triglycerides and postprandial lipemia were increased and HDL cholesterol (HDL-C) was decreased in hypertriglyceridemic men compared with control subjects ( P P P r =−.504, P =.014). Structural equation modeling of the association structures between HDL and fasting and postprandial triglycerides, endothelial lipases, and CETP in both groups indicated that the overall regression models for the two groups differed ( P P |
| Databáze: | OpenAIRE |
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