| Autor: |
Xiang-Yang, Yu, Sheng-Cheng, Lin, Meng-Qi, Zhang, Xiao-Tong, Guo, Kai, Ma, Li-Xu, Wang, Wen-Ting, Huang, Zhe, Wang, Xin, Yu, Chun-Guang, Wang, Lan-Jun, Zhang, Zhen-Tao, Yu |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
World Journal of Gastrointestinal Oncology. 14:498-510 |
| ISSN: |
1948-5204 |
| DOI: |
10.4251/wjgo.v14.i2.498 |
| Popis: |
Alpha-L-fucosidase-1 (FUCA1) has been demonstrated to play opposing regulatory roles in adenocarcinoma and non-adenocarcinoma. Moreover, recent studies reported that FUCA1 could decrease the invasion capability by downregulating matrix metalloproteinase 9 (MMP-9) expression. However, the potential role and prognostic significance of FUCA1 in esophageal squamous cell carcinoma (ESCC) have not yet been explored.To evaluate the status, association, and prognostic value of FUCA1 and MMP-9 expression in ESCC.Patients who underwent esophagectomy for ESCC between January 1, 2014, and December 31, 2014 at Sun Yat-Sen University Cancer Center were enrolled. The expression status of FUCA1 and MMP-9 in cancerous tissues was detected using immunohistochemistry. In addition, the expression profiles of theHigh expression of FUCA1 and MMP-9 was found in 90 patients (75.6%) and 62 patients (52.1%), respectively. In the high FUCA1 expression group, the constituent ratios of patients with stage III disease (61.1%FUCA1 cooperation with MMP-9 may have a major role in affecting the ESCC invasion and metastatic capability, and serve as a valuable prognostic biomarker in ESCC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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