Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes
| Autor: | Jacopo Forte, Carlotta Marianecci, Maria Carafa, Federica Rinaldi, Maria Grazia Ammendolia, Elena Del Favero, Laura Cantù, Patrizia Nadia Hanieh, Chiara Di Meo |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Serum
Biocompatibility Pharmaceutical Science Organic chemistry HA-Chol derivative Article Analytical Chemistry QD241-441 Drug Delivery Systems Drug Stability Biomimetic Materials Drug Discovery Amphiphile Animals Niosome Physical and Theoretical Chemistry Hyaluronic Acid Particle Size mimetic membranes Liposome Chemistry tumor targeting fluorescence ha-chol derivative niosomes saxs tem animals biomimetic materials cattle cell membrane cholesterol drug delivery systems drug stability hyaluronan receptors hyaluronic acid liposomes nanostructures particle size serum Cell Membrane Biological membrane SAXS Nanostructures Membrane Cholesterol Hyaluronan Receptors Chemistry (miscellaneous) Drug delivery Liposomes Biophysics TEM Molecular Medicine Cattle Nanocarriers |
| Zdroj: | Molecules 'Molecules ', vol: 26, pages: 3434-13434-16 (2021) Molecules, Vol 26, Iss 3434, p 3434 (2021) Volume 26 Issue 11 |
| ISSN: | 1420-3049 |
| Popis: | Hyaluronic acid (HA) is one of the most used biopolymers in the development of drug delivery systems, due to its biocompatibility, biodegradability, non-immunogenicity and intrinsic-targeting properties. HA specifically binds to CD44 this property combined to the EPR effect could provide an option for reinforced active tumor targeting by nanocarriers, improving drug uptake by the cancer cells via the HA-CD44 receptor-mediated endocytosis pathway. Moreover, HA can be easily chemically modified to tailor its physico-chemical properties in view of specific applications. The derivatization with cholesterol confers to HA an amphiphilic character, and then the ability of anchoring to niosomes. HA-Chol was then used to coat Span® or Tween® niosomes providing them with an intrinsic targeting shell. The nanocarrier physico-chemical properties were analyzed in terms of hydrodynamic diameter, ζ-potential, and bilayer structural features to evaluate the difference between naked and HA-coated niosomes. Niosomes stability was evaluated over time and in bovine serum. Moreover, interaction properties of HA-coated nanovesicles with model membranes, namely liposomes, were studied, to obtain insights on their interaction behavior with biological membranes in future experiments. The obtained coated systems showed good chemical physical features and represent a good opportunity to carry out active targeting strategies. |
| Databáze: | OpenAIRE |
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