Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression
| Autor: | Brandon J. Wainwright, Rehan Villani, Mathias Francois, Edwige Roy, Kiarash Khosrotehrani, Seen Ling Sim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Skin Neoplasms Notch signaling pathway Mice Transgenic Dermatology Dominant-Negative Mutation Biology Severity of Illness Index Biochemistry Ectopic Gene Expression Mice 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine SOXF Transcription Factors medicine Animals Humans Hedgehog Proteins Basal cell carcinoma Molecular Biology Hedgehog HEY1 Transcription factor Receptors Notch integumentary system Epidermis (botany) medicine.disease Gene Expression Regulation Neoplastic Patched-1 Receptor Disease Models Animal 030104 developmental biology Carcinoma Basal Cell Mutation Cancer research Ectopic expression Epidermis Signal Transduction |
| Zdroj: | Journal of Dermatological Science. 98:179-185 |
| ISSN: | 0923-1811 |
| Popis: | Background Basal Cell Carcinoma is the most common tumour and yet much remains to be determined regarding the molecular mechanisms that leads to its development. Hedgehog signal activation is sufficient for BCC induction, but the molecular mediators of BCC growth are not well understood. SoxF transcription factor Sox18 has been identified in human BCC, but its role in growth of the tumour is as yet unknown. Objective To determine if Sox18 is involved in the regulation of Basal Cell Carcinoma growth. Methods We analysed the function of Sox18 by combining a dominant negative Sox18 mouse model, Sox18+/OP with murine BCC Results We determine that Sox18 is ectopically expressed in the epidermal cells of a murine model of Basal Cell Carcinoma. We then show that dominant negative mutation of Sox18 increases the severity of murine Basal Cell Carcinoma. Finally, decreased Hey1 in Sox18+/OP BCC suggests Sox18 may negatively regulate BCC progression via Notch signaling. Conclusions These data suggest that Sox18 is a hedgehog regulated mediator of tumour suppression within Basal Cell Carcinoma epidermis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect